UniProt P09769
Tyrosine-protein kinase Fgr (P09769)
Tyrosine-protein kinase Fgr (UniProt P09769), EC 2.7.10.2: 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P09769
- Protein
- Tyrosine-protein kinase Fgr
- EC
- 2.7.10.2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 13 · 2 records with a druggable one
Structures
5 records of P09769 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7JT9 | Fgr SH3 domain crystal structure | x-ray diffraction | A | — | — |
| 7JT9 | Fgr SH3 domain crystal structure | x-ray diffraction | A | — | — |
| 7UY0 | Crystal structure of human Fgr tyrosine kinase in complex with A-419259 | x-ray diffraction | A, B | VSE, CL, PO4 | 9 (best 0.82) |
| 7UY3 | Crystal structure of human Fgr tyrosine kinase in complex with TL02-59 | x-ray diffraction | A | OJL, PO4 | 4 (best 0.79) |
| P09769 | AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fgr (P09769) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 2 records
- CL · Chloride ion · in 1 record
- OJL · 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide · in 1 record
- VSE · 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
Experiment against prediction
- 7UY0 chain B against the predicted model P09769: TM-score 0.98, RMSD 1.50 Å
- 7UY0 chain A against the predicted model P09769: TM-score 0.97, RMSD 1.43 Å
- 7JT9 chain A against the predicted model P09769: TM-score 0.84, RMSD 1.89 Å
- 7JT9 chain A against the predicted model P09769: TM-score 0.84, RMSD 1.89 Å
- 7UY3 chain A against the predicted model P09769: TM-score 0.76, RMSD 4.07 Å
Elsewhere
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