UniProt P09467
Fructose-1,6-bisphosphatase 1 (P09467)
Fructose-1,6-bisphosphatase 1 (UniProt P09467), EC 3.1.3.11: 43 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 182 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P09467
- Protein
- Fructose-1,6-bisphosphatase 1
- EC
- 3.1.3.11
- Experimental structures
- 43
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 182 · 10 records with a druggable one
Structures
44 records of P09467 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FTA | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate, 1-phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | — | — |
| 1FTA | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate, 1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | — | — |
| 2JJK | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate -1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | — | — |
| 2JJK | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate -1-phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | — | — |
| 2VT5 | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate -1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2VT5 | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate -1-phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WBB | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate-1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WBB | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate-1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WBD | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate-1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WBD | Fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate-1- phosphohydrolase) (E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2Y5K | Orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase | x-ray diffraction | A, B, C, D | — | — |
| 2Y5K | Orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase | x-ray diffraction | A, B, C, D | — | — |
| 2Y5L | orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2Y5L | Orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3A29 | Crystal structure of human liver FBPase in complex with tricyclic inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3A29 | Crystal structure of human liver fbpase in complex with tricyclic inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3KBZ | Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6 | x-ray diffraction | A, B, C, D | — | — |
| 3KBZ | Crystal structure of human liver fbpase in complex with tricyclic inhibitor 6 | x-ray diffraction | A, B, C, D | — | — |
| 3KC0 | Crystal structure of human liver FBPase in complex with tricyclic inhibitor 10b | x-ray diffraction | A, B, C, D | — | — |
| 3KC0 | Crystal structure of human liver fbpase in complex with tricyclic inhibitor 10B | x-ray diffraction | A, B, C, D | — | — |
| 3KC1 | Crystal structure of human liver FBPase in complex with tricyclic inhibitor 19a | x-ray diffraction | A, B, C, D | — | — |
| 3KC1 | Crystal structure of human liver fbpase in complex with tricyclic inhibitor 19A | x-ray diffraction | A, B, C, D | — | — |
| 4MJO | Human liver fructose-1,6-bisphosphatase(d-fructose-1,6-bisphosphate, 1-phosphohydrolase)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4MJO | Human liver fructose-1,6-BISPHOSPHATASE(D-fructose-1,6-bisphosphate, 1-phosphohydrolase)… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5LDZ | Quadruple space group ambiguity due to rotational and translational non-crystallographic symmetry… | x-ray diffraction | A, B, C, D, E, F | ZN, SO4, CL | 20 (best 0.83) |
| 5LDZ | Quadruple space group ambiguity due to rotational and translational non-crystallographic symmetry… | x-ray diffraction | A, B, C, D, E, F | ZN, SO4, CL | — |
| 6LW2 | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | EW0 | 20 (best 0.84) |
| 6LW2 | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | EW0 | — |
| 7C9Q | Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP | x-ray diffraction | A, C, D, B | AMP, MG | 20 (best 0.88) |
| 7C9Q | Crystal structure of human liver fructose-1,6-bisphoaphatase complex with MG2+ and AMP | x-ray diffraction | A, C, D, B | AMP, MG | — |
| 7CVH | Human Fructose-1,6-bisphosphatase 1 in complex with geranylgeranyl diphosphate | x-ray diffraction | A, C, B, D | FBP, MG, AMP, GRG | 19 (best 0.85) |
| 7CVH | Human fructose-1,6-bisphosphatase 1 in complex with geranylgeranyl diphosphate | x-ray diffraction | A, C, B, D | FBP, MG, AMP, GRG | — |
| 7CVN | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | GJO, FBP | 19 (best 0.85) |
| 7CVN | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | GJO, FBP | — |
| 7CWE | Human Fructose-1,6-bisphosphatase 1 in APO R-state | x-ray diffraction | A, B | MG | 7 (best 0.72) |
| 7CWE | Human fructose-1,6-bisphosphatase 1 in apo R-state | x-ray diffraction | A, B | MG | — |
| 7EZF | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | 0KI, FBP | 20 (best 0.86) |
| 7EZF | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | 0KI, FBP | — |
| 7EZP | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | FBP, 0GI | 20 (best 0.84) |
| 7EZP | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | FBP, 0GI | — |
| 7EZR | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | 0H1, FBP | 18 (best 0.84) |
| 7EZR | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | x-ray diffraction | A, B, C, D | 0H1, FBP | — |
| 7WVB | Human Fructose-1,6-bisphosphatase 1 mutant R50A in APO R-state | x-ray diffraction | A, B, C, D | — | 19 (best 0.80) |
| P09467 | AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase 1 (P09467) | predicted | A | — | — |
Ligands
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · in 10 records
- MG · Magnesium ion · in 6 records
- AMP · Adenosine monophosphate · in 4 records
- 0GI · 3-(3-hydroxy-3-oxopropyl)-5-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid · in 2 records
- 0H1 · 5-ethyl-7-nitro-3-[3-oxidanylidene-3-(thiophen-2-ylsulfonylamino)propyl]-1H-indole-2-carboxylic acid · in 2 records
- 0KI · 7-chloranyl-5-ethyl-3-(3-hydroxy-3-oxopropyl)-1H-indole-2-carboxylic acid · in 2 records
- CL · Chloride ion · in 2 records
- EW0 · 7-chloranyl-4-[(3-methoxyphenyl)amino]-N-(4-methoxyphenyl)sulfonyl-1-methyl-indole-2-carboxamide · in 2 records
- GJO · 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide · in 2 records
- GRG · Geranylgeranyl diphosphate · in 2 records
- SO4 · Sulfate ion · in 2 records
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 7WVB chain C against the predicted model P09467: TM-score 0.99, RMSD 0.61 Å
- 7WVB chain D against the predicted model P09467: TM-score 0.99, RMSD 0.64 Å
- 7WVB chain B against the predicted model P09467: TM-score 0.99, RMSD 0.74 Å
- 7WVB chain A against the predicted model P09467: TM-score 0.99, RMSD 0.79 Å
- 5LDZ chain F against the predicted model P09467: TM-score 0.99, RMSD 1.01 Å
- 5LDZ chain F against the predicted model P09467: TM-score 0.99, RMSD 1.01 Å
- 5LDZ chain A against the predicted model P09467: TM-score 0.99, RMSD 1.03 Å
- 5LDZ chain A against the predicted model P09467: TM-score 0.99, RMSD 1.03 Å
- 5LDZ chain B against the predicted model P09467: TM-score 0.98, RMSD 1.05 Å
- 5LDZ chain B against the predicted model P09467: TM-score 0.98, RMSD 1.05 Å
Elsewhere
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