UniProt P09119
Cell division control protein 6 (P09119)
Cell division control protein 6 (UniProt P09119): 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09119
- Protein
- Cell division control protein 6
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 55 · 9 records with a druggable one
Structures
15 records of P09119 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | electron microscopy | 9 | AGS | 4 (best 0.87) |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 | electron microscopy | 9 | AGS | — |
| 6WGC | Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD… | electron microscopy | 9 | AGS | 7 (best 0.87) |
| 6WGC | Atomic model of semi-attached mutant occm-DNA complex (orc-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | 9 | AGS | — |
| 6WGG | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | electron microscopy | 9 | AGS | 7 (best 0.88) |
| 6WGG | Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | 9 | AGS | — |
| 6WGI | Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at… | electron microscopy | 9 | AGS | 6 (best 0.88) |
| 6WGI | Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on DNA at… | electron microscopy | 9 | AGS | — |
| 7MCA | Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6… | electron microscopy | I | AGS, MG | 9 (best 0.88) |
| 7MCA | Structure of the S. cerevisiae origin recognition complex bound to the replication initiator CDC6… | electron microscopy | I | AGS, MG | — |
| 7TJI | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain | electron microscopy | I | ATP, MG | 5 (best 0.83) |
| 7TJJ | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain | electron microscopy | I | ATP, MG | 7 (best 0.88) |
| 7TJK | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain | electron microscopy | I | ATP, MG | 7 (best 0.88) |
| 9BCX | Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5… | electron microscopy | I | MG | 3 (best 0.84) |
| P09119 | AlphaFold monomer V2.0 prediction for cell division control protein 6 (P09119) | predicted | A | — | — |
Ligands
Experiment against prediction
- 9BCX chain I against the predicted model P09119: TM-score 0.80, RMSD 3.77 Å
- 5V8F chain 9 against the predicted model P09119: TM-score 0.78, RMSD 3.55 Å
- 5V8F chain 9 against the predicted model P09119: TM-score 0.78, RMSD 3.55 Å
- 7TJK chain I against the predicted model P09119: TM-score 0.78, RMSD 4.41 Å
- 7TJI chain I against the predicted model P09119: TM-score 0.78, RMSD 4.31 Å
- 7TJJ chain I against the predicted model P09119: TM-score 0.76, RMSD 4.60 Å
- 7MCA chain I against the predicted model P09119: TM-score 0.73, RMSD 4.45 Å
- 7MCA chain I against the predicted model P09119: TM-score 0.73, RMSD 4.45 Å
- 6WGC chain 9 against the predicted model P09119: TM-score 0.71, RMSD 4.94 Å
- 6WGC chain 9 against the predicted model P09119: TM-score 0.71, RMSD 4.94 Å
Elsewhere
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