UniProt P08729

Keratin, type II cytoskeletal 7 (P08729)

Keratin, type II cytoskeletal 7 (UniProt P08729): 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P08729
Protein: Keratin, type II cytoskeletal 7
Experimental structures: 2
Predicted models: 1
Ligands: 2
Pockets: 9 · 1 record with a druggable one

Structures

3 records of P08729 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4XIF	Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (keratin-7)	x-ray diffraction	E, F, G, H	SO4, 12V	9 (best 0.83)
4XIF	Human ogt in complex with udp-5S-glcnac and substrate peptide (keratin-7)	x-ray diffraction	E, F, G, H	—	—
P08729	AlphaFold monomer V2.0 prediction for keratin, type II cytoskeletal 7 (P08729)	predicted	A	—	—

Ligands

12V · (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3, 4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate · in 1 record
SO4 · Sulfate ion · in 1 record

Experiment against prediction

4XIF chain E against the predicted model P08729: TM-score 0.31, RMSD 1.47 Å
4XIF chain E against the predicted model P08729: TM-score 0.31, RMSD 1.47 Å

Elsewhere

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