UniProt P08574

Cytochrome c1, heme protein, mitochondrial (P08574)

Cytochrome c1, heme protein, mitochondrial (UniProt P08574): 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…

UniProt: P08574
Protein: Cytochrome c1, heme protein, mitochondrial
Experimental structures: 3
Predicted models: 1
Ligands: 4
Pockets: 3 · 2 records with a druggable one

Structures

4 records of P08574 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5XTE	Cryo-EM structure of human respiratory complex III (cytochrome BC1 complex)	electron microscopy	H, U	PEE, HEC, CDL, PLX	—
5XTH	Cryo-EM structure of human respiratory supercomplex I1III2IV1	electron microscopy	AH, AU	PEE, HEC, CDL, PLX	2 (best 0.84)
5XTI	Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2	electron microscopy	AH, AU	PEE, HEC, CDL, PLX	1 (best 0.85)
P08574	AlphaFold monomer V2.0 prediction for cytochrome C1, heme protein, mitochondrial (P08574)	predicted	A	—	—

Ligands

CDL · Cardiolipin · in 3 records
HEC · Heme C · in 3 records
PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 3 records
PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 3 records

Experiment against prediction

5XTI chain AH against the predicted model P08574: TM-score 0.97, RMSD 1.27 Å
5XTH chain AH against the predicted model P08574: TM-score 0.97, RMSD 1.27 Å
5XTE chain H against the predicted model P08574: TM-score 0.97, RMSD 1.27 Å
5XTH chain AU against the predicted model P08574: TM-score 0.97, RMSD 1.31 Å
5XTI chain AU against the predicted model P08574: TM-score 0.97, RMSD 1.31 Å
5XTE chain U against the predicted model P08574: TM-score 0.97, RMSD 1.31 Å

Elsewhere

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