UniProt P08473
Neprilysin (P08473)
Neprilysin (UniProt P08473), EC 3.4.24.11: 27 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08473
- Protein
- Neprilysin
- EC
- 3.4.24.11
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 67 · 6 records with a druggable one
Structures
28 records of P08473 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DMT | Structure of human neutral endopeptidase complexed with phosphoramidon | x-ray diffraction | A | — | — |
| 1DMT | Structure of human neutral endopeptidase complexed with phosphoramidon | x-ray diffraction | A | — | — |
| 1R1H | Structural analysis of neprilysin with various specific and potent inhibitors | x-ray diffraction | A | — | — |
| 1R1H | Structural analysis of neprilysin with various specific and potent inhibitors | x-ray diffraction | A | — | — |
| 1R1I | Structural analysis of neprilysin with various specific and potent inhibitors | x-ray diffraction | A | — | — |
| 1R1I | Structural analysis of neprilysin with various specific and potent inhibitors | x-ray diffraction | A | — | — |
| 1R1J | Structural analysis of neprilysin with various specific and potent inhibitors | x-ray diffraction | A | — | — |
| 1R1J | Structural analysis of neprilysin with various specific and potent inhibitors | x-ray diffraction | A | — | — |
| 1Y8J | Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor | x-ray diffraction | A | — | — |
| 1Y8J | Crystal structure of human nep complexed with an IMIDAZO[4,5- C]PYRIDINE inhibitor | x-ray diffraction | A | — | — |
| 2QPJ | Human NEP complexed with a bifunctional NEP/DPP IV inhibitor | x-ray diffraction | A | — | — |
| 2QPJ | Human nep complexed with a bifunctional NEP/DPP IV inhibitor | x-ray diffraction | A | — | — |
| 2YB9 | Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid. | x-ray diffraction | A | — | — |
| 2YB9 | Crystal structure of human neutral endopeptidase complexed with a heteroarylalanine diacid. | x-ray diffraction | A | — | — |
| 4CTH | Neprilysin variant G399V,G714K in complex with phosphoramidon | x-ray diffraction | A | — | — |
| 4CTH | Neprilysin variant G399V,G714K in complex with phosphoramidon | x-ray diffraction | A | — | — |
| 5JMY | Neprilysin complexed with LBQ657 | x-ray diffraction | A, B | NAG, ZN, 6LD | 20 (best 0.83) |
| 5JMY | Neprilysin complexed with LBQ657 | x-ray diffraction | A, B | — | — |
| 6GID | High resolution crystal structure of substrate-free human neprilysin | x-ray diffraction | A | NAG, ZN, NO3, PO4 | — |
| 6SH2 | Crystal structure of human neprilysin E584D in complex with C-type natriuretic peptide. | x-ray diffraction | AAA | NAG, ZN, CL | 8 (best 0.63) |
| 6SUK | Crystal structure of neprilysin in complex with omapatrilat. | x-ray diffraction | A | ZN, NAG, FT8 | — |
| 6SVY | Crystal structure of Neprilysin in complex with Sampatrilat-ASP. | x-ray diffraction | A | ZN, D0W, NAG | 7 (best 0.76) |
| 6SVY | Crystal structure of neprilysin in complex with sampatrilat-asp. | x-ray diffraction | A | ZN, D0W, NAG | — |
| 6THP | Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'-chlorobiphenyl-4-yl)propan-2-ylamino… | x-ray diffraction | A, B | NAG, ZN, N9Q | 18 (best 0.83) |
| 6THP | Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'… | x-ray diffraction | A, B | NAG, ZN, N9Q | — |
| 6XVP | Crystal structure of Neprilysin in complex with Sampatrilat. | x-ray diffraction | A | ZN, D0Z, NAG | 8 (best 0.67) |
| 6XVP | Crystal structure of neprilysin in complex with sampatrilat. | x-ray diffraction | A | ZN, D0Z, NAG | — |
| P08473 | AlphaFold monomer V2.0 prediction for neprilysin (P08473) | predicted | A | — | 6 (best 0.76) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 10 records
- ZN · Zinc ion · in 10 records
- D0W · Sampatrilat-Asp · in 2 records
- D0Z · Sampatrilat · in 2 records
- N9Q · 4-[[(2~{R})-1-[4-(3-chlorophenyl)phenyl]-4-oxidanyl-4-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butanoic acid · in 2 records
- 6LD · Sacubitrilat · in 1 record
- CL · Chloride ion · in 1 record
- FT8 · Omapatrilat · in 1 record
- NO3 · Nitrate ion · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 6SUK chain A against the predicted model P08473: TM-score 1.00, RMSD 0.22 Å
- 1R1H chain A against the predicted model P08473: TM-score 1.00, RMSD 0.28 Å
- 1R1H chain A against the predicted model P08473: TM-score 1.00, RMSD 0.28 Å
- 6SVY chain A against the predicted model P08473: TM-score 1.00, RMSD 0.28 Å
- 6SVY chain A against the predicted model P08473: TM-score 1.00, RMSD 0.28 Å
- 1R1J chain A against the predicted model P08473: TM-score 1.00, RMSD 0.28 Å
- 1R1J chain A against the predicted model P08473: TM-score 1.00, RMSD 0.28 Å
- 6XVP chain A against the predicted model P08473: TM-score 1.00, RMSD 0.30 Å
- 6XVP chain A against the predicted model P08473: TM-score 1.00, RMSD 0.30 Å
- 1Y8J chain A against the predicted model P08473: TM-score 1.00, RMSD 0.31 Å
Elsewhere
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