UniProt P08049
Neprilysin (P08049)
Neprilysin (UniProt P08049), EC 3.4.24.11: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08049
- Protein
- Neprilysin
- EC
- 3.4.24.11
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 23 · 2 records with a druggable one
Structures
7 records of P08049 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XBH | Soluble rabbit neprilysin | x-ray diffraction | A, B | — | — |
| 4XBH | Soluble rabbit neprilysin | x-ray diffraction | A, B | — | — |
| 4ZR5 | Soluble rabbit neprilysin in complex with phosphoramidon | x-ray diffraction | A, B | — | — |
| 4ZR5 | Soluble rabbit neprilysin in complex with phosphoramidon | x-ray diffraction | A, B | — | — |
| 5V48 | Soluble rabbit neprilysin in complex with thiorphan | x-ray diffraction | A, B | NAG, ZN, TIO | 14 (best 0.83) |
| 5V48 | Soluble rabbit neprilysin in complex with thiorphan | x-ray diffraction | A, B | NAG, ZN, TIO | — |
| P08049 | AlphaFold monomer V2.0 prediction for neprilysin (P08049) | predicted | A | — | 9 (best 0.64) |
Ligands
Experiment against prediction
- 4XBH chain A against the predicted model P08049: TM-score 1.00, RMSD 0.54 Å
- 4XBH chain A against the predicted model P08049: TM-score 1.00, RMSD 0.54 Å
- 5V48 chain A against the predicted model P08049: TM-score 1.00, RMSD 0.56 Å
- 5V48 chain A against the predicted model P08049: TM-score 1.00, RMSD 0.56 Å
- 5V48 chain B against the predicted model P08049: TM-score 1.00, RMSD 0.59 Å
- 4ZR5 chain A against the predicted model P08049: TM-score 0.99, RMSD 0.58 Å
- 4ZR5 chain A against the predicted model P08049: TM-score 0.99, RMSD 0.58 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.