UniProt P07012
Peptide chain release factor RF2 (P07012)
Peptide chain release factor RF2 (UniProt P07012): 26 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 39 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07012
- Protein
- Peptide chain release factor RF2
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 39 · 14 records with a druggable one
Structures
27 records of P07012 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GQE | Polypeptide Chain Release Factor 2 (RF2) from Escherichia coli | x-ray diffraction | A | — | — |
| 1GQE | Polypeptide chain release factor 2 (RF2) from escherichia COLI | x-ray diffraction | A | — | — |
| 1MI6 | Docking of the modified RF2 X-ray structure into the Low Resolution Cryo-EM map of RF2 E.coli 70S… | electron microscopy | A | — | — |
| 1MI6 | Docking of the modified RF2 X-ray structure into the low resolution cryo-EM MAP of RF2 E.COLI 70S… | electron microscopy | A | — | — |
| 1ML5 | Structure of the E. coli ribosomal termination complex with release factor 2 | electron microscopy | Z | — | — |
| 1ML5 | Structure of the E. COLI ribosomal termination complex with release factor 2 | electron microscopy | Z | — | — |
| 5CZP | 70S termination complex containing E. coli RF2 | x-ray diffraction | QY, XY | MG | 4 (best 0.89) |
| 5DFE | 70S termination complex containing E. coli RF2 | x-ray diffraction | QY, XY | MG | 3 (best 0.88) |
| 5H5U | Mechanistic insights into the alternative translation termination by ArfA and RF2 | electron microscopy | 4 | — | 4 (best 0.88) |
| 5MDV | Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state) | electron microscopy | 7 | FME | — |
| 5MDW | Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state) | electron microscopy | 7 | — | — |
| 5MGP | Structural basis for ArfA-RF2 mediated translation termination on stop-codon lacking mRNAs | electron microscopy | z | — | 2 (best 0.88) |
| 5U4I | Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome | electron microscopy | v | — | — |
| 5U4J | Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome | electron microscopy | v | — | 4 (best 0.83) |
| 5U4J | Structural basis of co-translational quality control by arfa and RF2 bound to ribosome | electron microscopy | v | — | — |
| 5U9F | 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II) | electron microscopy | Z | — | 3 (best 0.87) |
| 5U9G | 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I) | electron microscopy | Z | — | 1 (best 0.82) |
| 6C4H | Conformation of methylated GGQ in the peptidyl transferase center during translation termination… | electron microscopy | v | — | 4 (best 0.84) |
| 6C4H | Conformation of methylated ggq in the peptidyl transferase center during translation termination… | electron microscopy | v | — | — |
| 6C4I | Conformation of methylated GGQ in the peptidyl transferase center during translation termination | electron microscopy | v | — | 4 (best 0.87) |
| 6OG7 | 70S termination complex with RF2 bound to the UGA codon. Non-rotated ribosome with RF2 bound… | electron microscopy | 8 | — | 2 (best 0.86) |
| 7O1C | Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to… | electron microscopy | B9 | — | — |
| 7OJ0 | Cryo-EM structure of 70S ribosome stalled with TnaC peptide and RF2 | electron microscopy | 8 | — | 1 (best 0.88) |
| 8P17 | E167K RF2 on E. coli 70S release complex with UGG (Structure II) | electron microscopy | 6 | — | 3 (best 0.87) |
| 8P18 | E167K RF2 on E. coli 70S release complex with UGG (Structure III) | electron microscopy | 6 | K | 1 (best 0.84) |
| 8QK7 | E167K RF2 on E. coli 70S release complex with UAA | electron microscopy | 6 | K | 1 (best 0.85) |
| P07012 | AlphaFold monomer V2.0 prediction for peptide chain release factor RF2 (P07012) | predicted | A | — | 2 (best 0.37) |
Ligands
Experiment against prediction
- 8P18 chain 6 against the predicted model P07012: TM-score 0.93, RMSD 1.97 Å
- 8P17 chain 6 against the predicted model P07012: TM-score 0.92, RMSD 2.03 Å
- 7O1C chain B9 against the predicted model P07012: TM-score 0.92, RMSD 2.03 Å
- 5CZP chain XY against the predicted model P07012: TM-score 0.92, RMSD 2.07 Å
- 5CZP chain QY against the predicted model P07012: TM-score 0.92, RMSD 2.07 Å
- 5DFE chain XY against the predicted model P07012: TM-score 0.92, RMSD 2.08 Å
- 5DFE chain QY against the predicted model P07012: TM-score 0.92, RMSD 2.10 Å
- 6C4I chain v against the predicted model P07012: TM-score 0.91, RMSD 2.35 Å
- 8QK7 chain 6 against the predicted model P07012: TM-score 0.91, RMSD 2.18 Å
- 5MDV chain 7 against the predicted model P07012: TM-score 0.91, RMSD 2.37 Å
Elsewhere
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