UniProt P06959
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (P06959)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (UniProt P06959), EC 2.3.1.12: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 36 pockets. Binding sites…
- UniProt
- P06959
- Protein
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate…
- EC
- 2.3.1.12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 36 · 3 records with a druggable one
Structures
9 records of P06959 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QJO | Innermost lipoyl domain of the pyruvate dehydrogenase from escherichia COLI | solution nmr | A | — | — |
| 1QJO | Innermost lipoyl domain of the pyruvate dehydrogenase from escherichia COLI | solution nmr | A | — | — |
| 2K7V | Deletions in a surface loop divert the folding of a protein domain into a metastable dimeric form | solution nmr | A, B | — | — |
| 2K7V | Deletions in a surface loop divert the folding of a protein domain into a metastable dimeric form | solution nmr | A, B | — | — |
| 7B9K | Cryo-EM structure of the dihydrolipoyl transacetylase cubic core of the E. COLI pyruvate… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 8OQJ | Peripheral subunit binding domain of the E. coli Dihydrolipoamide Acetyltransferase (E2) of the… | x-ray diffraction | A, B | ZN | — |
| 8ORB | 24-meric catalytic domain of dihydrolipoamide acetyltransferase (E2) of the E. coli pyruvate… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y | — | 20 (best 0.80) |
| 8OSY | Trimeric catalytic domain of the E. coli Dihydrolipoamide Acetyltransferase (E2) of the pyruvate… | x-ray diffraction | A, B, C, D | — | 14 (best 0.81) |
| P06959 | AlphaFold monomer V2.0 prediction for dihydrolipoyllysine-residue acetyltransferase component of… | predicted | A | — | 2 (best 0.65) |
Ligands
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 8ORB chain D against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain E against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain R against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain S against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain W against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain Y against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain F against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain G against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain M against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
- 8ORB chain N against the predicted model P06959: TM-score 0.98, RMSD 0.85 Å
Elsewhere
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