UniProt P06839
General transcription and DNA repair factor IIH helicase subunit XPD (P06839)
General transcription and DNA repair factor IIH helicase subunit XPD (UniProt P06839), EC 3.6.4.12, 5.6.2.3: 34 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 72 pockets. Binding sites, druggability…
- UniProt
- P06839
- Protein
- General transcription and DNA repair factor IIH helicase subunit XPD
- EC
- 3.6.4.12, 5.6.2.3
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 72 · 18 records with a druggable one
Structures
35 records of P06839 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FMF | the P-lobe of RNA polymerase II pre-initiation complex | electron microscopy | Y | — | — |
| 5FMF | The P-lobe of RNA polymerase II pre-initiation complex | electron microscopy | Y | — | — |
| 5OQJ | Structure of yeast transcription pre-initiation complex with tfiih | electron microscopy | 0 | SF4 | — |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | 0 | SF4 | 3 (best 0.83) |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | 0 | SF4 | — |
| 5SVA | Mediator-RNA Polymerase II Pre-Initiation Complex | electron microscopy | Y | — | 1 (best 0.78) |
| 5SVA | Mediator-RNA polymerase II pre-initiation complex | electron microscopy | Y | — | — |
| 6GYM | Structure of a yeast closed complex with distorted DNA (CCdist) | electron microscopy | 0 | SF4 | — |
| 6GYM | Structure of a yeast closed complex with distorted DNA (ccdist) | electron microscopy | 0 | SF4 | — |
| 7K01 | Structure of TFIIH in TFIIH/Rad4-Rad23-Rad33 DNA opening complex | electron microscopy | 0 | SF4 | 6 (best 0.80) |
| 7K01 | Structure of tfiih in TFIIH/RAD4-RAD23-RAD33 DNA opening complex | electron microscopy | 0 | SF4 | — |
| 7K04 | Structure of TFIIH/Rad4-Rad23-Rad33/DNA in DNA opening | electron microscopy | 0 | SF4 | 5 (best 0.84) |
| 7K04 | Structure of TFIIH/RAD4-RAD23-RAD33/DNA in DNA opening | electron microscopy | 0 | SF4 | — |
| 7M2U | Nucleotide Excision Repair complex TFIIH Rad4-33 | electron microscopy | 0 | SF4 | 6 (best 0.79) |
| 7M2U | Nucleotide excision repair complex tfiih RAD4-33 | electron microscopy | 0 | SF4 | — |
| 7O4I | Yeast RNA polymerase II transcription pre-initiation complex with initial transcription bubble | electron microscopy | 0 | SF4 | 2 (best 0.82) |
| 7O4I | Yeast RNA polymerase II transcription pre-initiation complex with initial transcription bubble | electron microscopy | 0 | SF4 | — |
| 7O4J | Yeast RNA polymerase II transcription pre-initiation complex (consensus) | electron microscopy | 0 | SF4 | 2 (best 0.83) |
| 7O4J | Yeast RNA polymerase II transcription pre-initiation complex (consensus) | electron microscopy | 0 | SF4 | — |
| 7O4K | Yeast TFIIH in the contracted state within the pre-initiation complex | electron microscopy | 0 | SF4 | 8 (best 0.80) |
| 7O4K | Yeast tfiih in the contracted state within the pre-initiation complex | electron microscopy | 0 | SF4 | — |
| 7O4L | Yeast TFIIH in the expanded state within the pre-initiation complex | electron microscopy | 0 | SF4 | 6 (best 0.84) |
| 7O4L | Yeast tfiih in the expanded state within the pre-initiation complex | electron microscopy | 0 | SF4 | — |
| 7O72 | Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA | electron microscopy | 0 | SF4 | 4 (best 0.83) |
| 7O72 | Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA | electron microscopy | 0 | SF4 | — |
| 7O73 | Yeast RNA polymerase II transcription pre-initiation complex with closed distorted promoter DNA | electron microscopy | 0 | SF4 | — |
| 7O75 | Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA | electron microscopy | 0 | SF4 | 3 (best 0.83) |
| 7O75 | Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA | electron microscopy | 0 | SF4 | — |
| 7ZS9 | Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A) | electron microscopy | 0 | SF4 | 2 (best 0.80) |
| 7ZSA | Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP… | electron microscopy | 0 | SF4 | 1 (best 0.85) |
| 7ZSB | Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP… | electron microscopy | 0 | SF4 | 2 (best 0.82) |
| 8CEN | Yeast RNA polymerase II transcription pre-initiation complex with core Mediator | electron microscopy | 0 | SF4 | 2 (best 0.83) |
| 8CEO | Yeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1… | electron microscopy | 0 | SF4 | 2 (best 0.81) |
| 8UOQ | Composite map of PIC_delta_TFIIK form2 | electron microscopy | 0 | SF4 | 5 (best 0.84) |
| P06839 | AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih helicase… | predicted | A | — | 12 (best 0.75) |
Ligands
- SF4 · Iron/sulfur cluster · in 30 records
Experiment against prediction
- 7O72 chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.30 Å
- 7O72 chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.30 Å
- 7O4I chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.30 Å
- 7O4I chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.30 Å
- 7O73 chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.31 Å
- 7O75 chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.31 Å
- 7O75 chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.31 Å
- 7O4L chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.31 Å
- 7O4L chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.31 Å
- 7O4J chain 0 against the predicted model P06839: TM-score 0.98, RMSD 1.31 Å
Elsewhere
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