UniProt P06710

DNA polymerase III subunit tau (P06710)

DNA polymerase III subunit tau (UniProt P06710), EC 2.7.7.7: 36 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 200 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…

UniProt: P06710
Protein: DNA polymerase III subunit tau
EC: 2.7.7.7
Experimental structures: 36
Predicted models: 1
Ligands: 6
Pockets: 200 · 12 records with a druggable one

Structures

37 records of P06710 in the MolNFT archive: 36 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1JR3	Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III	x-ray diffraction	A, B, C	—	—
1JR3	Crystal structure of the processivity clamp loader gamma complex of E. COLI DNA polymerase III	x-ray diffraction	A, B, C	—	—
1NJF	Nucleotide bound form of an isolated E. coli clamp loader gamma subunit	x-ray diffraction	A, B, C, D	—	—
1NJF	Nucleotide bound form of an isolated E. COLI clamp loader gamma subunit	x-ray diffraction	A, B, C, D	—	—
1NJG	Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit	x-ray diffraction	A, B	—	—
1NJG	Nucleotide-free form of an isolated E. COLI clamp loader gamma subunit	x-ray diffraction	A, B	—	—
1XXH	ATPgS Bound E. Coli Clamp Loader Complex	x-ray diffraction	B, C, D, G, H, I	—	—
1XXH	Atpgs bound E. COLI clamp loader complex	x-ray diffraction	B, C, D, G, H, I	—	—
1XXI	ADP Bound E. coli Clamp Loader Complex	x-ray diffraction	B, C, D, G, H, I	—	—
1XXI	ADP bound E. COLI clamp loader complex	x-ray diffraction	B, C, D, G, H, I	—	—
2AYA	Solution Structure of the C-Terminal 14 kDa Domain of the tau subunit from Escherichia coli DNA…	solution nmr	A	—	—
2AYA	Solution structure of the C-terminal 14 kda domain of the tau subunit from escherichia COLI DNA…	solution nmr	A	—	—
3GLF	Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA	x-ray diffraction	B, C, D, G, H, I	—	—
3GLF	Crystal structure of the ecoli clamp loader bound to primer-template DNA	x-ray diffraction	B, C, D, G, H, I	—	—
3GLG	Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA	x-ray diffraction	B, C, D, G, H, I	—	—
3GLG	Crystal structure of a mutant (GAMMAT157A) E. COLI clamp loader bound to primer-template DNA	x-ray diffraction	B, C, D, G, H, I	—	—
3GLH	Crystal Structure of the E. coli clamp loader bound to Psi Peptide	x-ray diffraction	B, C, D, G, H, I, L, M, N	—	—
3GLH	Crystal structure of the E. COLI clamp loader bound to psi peptide	x-ray diffraction	B, C, D, G, H, I, L, M, N	—	—
3GLI	Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide	x-ray diffraction	B, C, D, G, H, I	—	—
3GLI	Crystal structure of the E. COLI clamp loader bound to primer-template DNA and psi peptide	x-ray diffraction	B, C, D, G, H, I	—	—
5FKU	cryo-EM structure of the E. coli replicative DNA polymerase complex in DNA free state (DNA…	electron microscopy	E	—	—
5FKU	Cryo-EM structure of the E. COLI replicative DNA polymerase complex in DNA free state (DNA…	electron microscopy	E	—	—
5FKV	cryo-EM structure of the E. coli replicative DNA polymerase complex bound to DNA (DNA polymerase…	electron microscopy	E	—	—
5FKV	Cryo-EM structure of the E. COLI replicative DNA polymerase complex bound to DNA (DNA polymerase…	electron microscopy	E	—	—
8GIY	E. coli clamp loader with closed clamp	electron microscopy	B, C, D	AGS, MG, ZN	16 (best 0.81)
8GIZ	E. coli clamp loader with open clamp	electron microscopy	B, C, D	AGS, MG, ZN	15 (best 0.85)
8GJ0	E. coli clamp loader with open clamp on primed template DNA (form 1)	electron microscopy	B, C, D	ADP, MG, ALF, ZN	14 (best 0.82)
8GJ2	E. coli clamp loader with closed clamp on primed template DNA	electron microscopy	B, C, D	ADP, MG, ALF, ZN	18 (best 0.83)
8GJ3	E. coli clamp loader on primed template DNA	electron microscopy	B, C, D	ADP, MG, ALF, ZN	19 (best 0.83)
8VAL	Structure of the E. coli clamp loader bound to the beta clamp in a Open-DNAp/t conformation	electron microscopy	B, C, D	ZN, ADP, BEF, MG	19 (best 0.82)
8VAN	Structure of the E. coli clamp loader bound to the beta clamp in an Initial-Binding conformation	electron microscopy	B, C, D	—	16 (best 0.81)
8VAP	Structure of the E. coli clamp loader bound to the beta clamp in a Fully-Open conformation	electron microscopy	B, C, D	ADP, BEF, MG, ZN	18 (best 0.84)
8VAQ	Structure of the E. coli clamp loader bound to the beta clamp in a Closed-DNA1 conformation	electron microscopy	B, C, D	ZN, ADP, MG, BEF	15 (best 0.85)
8VAR	Structure of the E. coli clamp loader bound to the beta clamp in a Closed-DNA2 conformation	electron microscopy	B, C, D	ZN, ADP, BEF, MG	16 (best 0.84)
8VAS	Structure of the E. coli clamp loader bound to the beta clamp in an Altered-Collar conformation	electron microscopy	B, C, D	ZN, ADP, BEF, MG	17 (best 0.84)
8VAT	Structure of the E. coli clamp loader bound to the beta clamp in a Open-RNAp/t conformation	electron microscopy	B, C, D	ZN, ADP, BEF, MG	17 (best 0.80)
P06710	AlphaFold monomer V2.0 prediction for DNA polymerase III subunit tau (P06710)	predicted	A	—	—

Ligands

MG · Magnesium ion · in 11 records
ZN · Zinc ion · in 11 records
ADP · Adenosine-5'-diphosphate · in 9 records
BEF · Beryllium trifluoride ion · in 6 records
ALF · Tetrafluoroaluminate ion · in 3 records
AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records

Experiment against prediction

1NJF chain C against the predicted model P06710: TM-score 0.98, RMSD 0.97 Å
1NJF chain C against the predicted model P06710: TM-score 0.98, RMSD 0.97 Å
1NJF chain D against the predicted model P06710: TM-score 0.98, RMSD 1.03 Å
1NJF chain D against the predicted model P06710: TM-score 0.98, RMSD 1.03 Å
1NJF chain A against the predicted model P06710: TM-score 0.97, RMSD 1.06 Å
1NJF chain A against the predicted model P06710: TM-score 0.97, RMSD 1.06 Å
1NJG chain A against the predicted model P06710: TM-score 0.96, RMSD 1.22 Å
1NJG chain A against the predicted model P06710: TM-score 0.96, RMSD 1.22 Å
1JR3 chain A against the predicted model P06710: TM-score 0.96, RMSD 1.47 Å
1JR3 chain A against the predicted model P06710: TM-score 0.96, RMSD 1.47 Å

Elsewhere

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