UniProt P06612
DNA topoisomerase 1 (P06612)
DNA topoisomerase 1 (UniProt P06612): 28 experimental structures and 1 predicted model on GenesisL1, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P06612
- Protein
- DNA topoisomerase 1
- Experimental structures
- 28
- Predicted models
- 1
- Pockets
- 8 · 1 record with a druggable one
Structures
29 records of P06612 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CY0 | Complex of E.COLI DNA topoisomerase I with 3'-5'-adenosine diphosphate | x-ray diffraction | A | — | — |
| 1CY0 | Complex of E.COLI DNA topoisomerase I with 3'-5'-adenosine diphosphate | x-ray diffraction | A | — | — |
| 1CY1 | Complex of E.COLI DNA topoisomerase I with 5'PTPTPT | x-ray diffraction | A | — | — |
| 1CY1 | Complex of E.COLI DNA topoisomerase I with 5'PTPTPT | x-ray diffraction | A | — | — |
| 1CY2 | Complex of E.COLI DNA topoisomerase I with TPTPTP3' | x-ray diffraction | A | — | — |
| 1CY2 | Complex of E.COLI DNA topoisomerase I with TPTPTP3' | x-ray diffraction | A | — | — |
| 1CY4 | COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'pTpTpTp3' | x-ray diffraction | A | — | — |
| 1CY4 | Complex of E.COLI DNA topoisomerase I with 5'PTPTPTP3' | x-ray diffraction | A | — | — |
| 1CY6 | Complex of E.COLI DNA topoisomerase I with 3' thymidine monophosphate | x-ray diffraction | A | — | — |
| 1CY6 | Complex of E.COLI DNA topoisomerase I with 3' thymidine monophosphate | x-ray diffraction | A | — | — |
| 1CY7 | Complex of E.COLI DNA topoisomerase I with 5'-thymidine monophosphate | x-ray diffraction | A | — | — |
| 1CY7 | Complex of E.COLI DNA topoisomerase I with 5'-thymidine monophosphate | x-ray diffraction | A | — | — |
| 1CY8 | Complex of E.COLI DNA topoisomerase I with 5'-thymidine monophosphate and 3'-thymidine monophosphate | x-ray diffraction | A | — | — |
| 1CY8 | Complex of E.COLI DNA topoisomerase I with 5'-thymidine monophosphate and 3'-thymidine monophosphate | x-ray diffraction | A | — | — |
| 1CY9 | Crystal structure of the 30 kda fragment of E. COLI DNA topoisomerase I. monoclinic form | x-ray diffraction | A, B | — | — |
| 1CY9 | Crystal structure of the 30 kda fragment of E. COLI DNA topoisomerase I. monoclinic form | x-ray diffraction | A, B | — | — |
| 1CYY | Crystal structure of the 30 kda fragment of E. COLI DNA topoisomerase I. hexagonal form | x-ray diffraction | A, B | — | — |
| 1CYY | Crystal structure of the 30 kda fragment of E. COLI DNA topoisomerase I. hexagonal form | x-ray diffraction | A, B | — | — |
| 1ECL | Amino terminal 67KDA domain of escherichia COLI DNA topoisomerase I (residues 2-590 of mature… | x-ray diffraction | A | — | — |
| 1ECL | Amino terminal 67KDA domain of escherichia COLI DNA topoisomerase I (residues 2-590 of mature… | x-ray diffraction | A | — | — |
| 1MW8 | Crystal Structure of a Complex between H365R mutant of 67 kDA N-terminal fragment of E. coli DNA… | x-ray diffraction | X | — | — |
| 1MW8 | Crystal structure of a complex between H365R mutant of 67 kda N- terminal fragment of E. COLI DNA… | x-ray diffraction | X | — | — |
| 1MW9 | Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I | x-ray diffraction | X | — | — |
| 1MW9 | Crystal structure of H365R mutant of 67 kda N-terminal fragment of E. COLI DNA topoisomerase I | x-ray diffraction | X | — | — |
| 1YUA | C-terminal domain of escherichia COLI topoisomerase I | solution nmr | A | — | — |
| 1YUA | C-terminal domain of escherichia COLI topoisomerase I | solution nmr | A | — | — |
| 3PWT | Crystal structure of mutant E.coli topoisomerase IA | x-ray diffraction | A | — | — |
| 3PWT | Crystal structure of mutant E.COLI topoisomerase ia | x-ray diffraction | A | — | — |
| P06612 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 1 (P06612) | predicted | A | — | 8 (best 0.68) |
Experiment against prediction
- 1MW8 chain X against the predicted model P06612: TM-score 0.97, RMSD 1.47 Å
- 1MW8 chain X against the predicted model P06612: TM-score 0.97, RMSD 1.47 Å
- 1CY2 chain A against the predicted model P06612: TM-score 0.97, RMSD 1.62 Å
- 1CY2 chain A against the predicted model P06612: TM-score 0.97, RMSD 1.62 Å
- 1CY1 chain A against the predicted model P06612: TM-score 0.97, RMSD 1.65 Å
- 1CY1 chain A against the predicted model P06612: TM-score 0.97, RMSD 1.65 Å
- 1MW9 chain X against the predicted model P06612: TM-score 0.97, RMSD 1.61 Å
- 1MW9 chain X against the predicted model P06612: TM-score 0.97, RMSD 1.61 Å
- 3PWT chain A against the predicted model P06612: TM-score 0.97, RMSD 1.74 Å
- 3PWT chain A against the predicted model P06612: TM-score 0.97, RMSD 1.74 Å
Elsewhere
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