UniProt P06126
T-cell surface glycoprotein CD1a (P06126)
T-cell surface glycoprotein CD1a (UniProt P06126): 24 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P06126
- Protein
- T-cell surface glycoprotein CD1a
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 31 · 6 records with a druggable one
Structures
25 records of P06126 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ONQ | Crystal Structure of CD1a in Complex with a Sulfatide | x-ray diffraction | A, C | — | — |
| 1ONQ | Crystal structure of CD1A in complex with a sulfatide | x-ray diffraction | A, C | — | — |
| 1XZ0 | Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide | x-ray diffraction | A, C | — | — |
| 1XZ0 | Crystal structure of CD1A in complex with a synthetic mycobactin lipopeptide | x-ray diffraction | A, C | — | — |
| 4X6C | CD1A ternary complex with lysophosphatidylcholine and BK6 TCR | x-ray diffraction | A, C | — | — |
| 4X6D | CD1A ternary complex with endogenous lipids and BK6 TCR | x-ray diffraction | A, C | — | — |
| 4X6E | CD1a binary complex with lysophosphatidylcholine | x-ray diffraction | A | — | — |
| 4X6E | CD1A binary complex with lysophosphatidylcholine | x-ray diffraction | A | — | — |
| 4X6F | CD1a binary complex with sphingomyelin | x-ray diffraction | A | — | — |
| 4X6F | CD1A binary complex with sphingomyelin | x-ray diffraction | A | — | — |
| 5J1A | Antigen presenting molecule | x-ray diffraction | A | 6F8 | 4 (best 0.86) |
| 5J1A | Antigen presenting molecule | x-ray diffraction | A | — | — |
| 7KOZ | CD1a-36:2 SM binary complex | x-ray diffraction | A | WU7, NAG | 5 (best 0.86) |
| 7KOZ | CD1A-36:2 sm binary complex | x-ray diffraction | A | WU7, NAG | — |
| 7KP0 | CD1a-42:1 SM binary complex | x-ray diffraction | A | WUA | 4 (best 0.84) |
| 7KP0 | CD1A-42:1 sm binary complex | x-ray diffraction | A | WUA | — |
| 7KP1 | CD1a-42:2 SM binary complex | x-ray diffraction | A | FO4 | 5 (best 0.84) |
| 7KP1 | CD1A-42:2 sm binary complex | x-ray diffraction | A | FO4 | — |
| 7RYM | CD1a-endo-gdTCR complex | x-ray diffraction | A | SO4 | 7 (best 0.84) |
| 7RYM | CD1A-endo-gdtcr complex | x-ray diffraction | A | SO4 | — |
| 7RYN | CD1A-sulfatide-gdtcr complex | x-ray diffraction | A | CIS, NAG, SO4 | — |
| 7RYO | CD1a-dideoxymycobactin-gdTCR complex | x-ray diffraction | A | WGR | 6 (best 0.84) |
| 7RYO | CD1A-dideoxymycobactin-gdtcr complex | x-ray diffraction | A | WGR | — |
| 7SH4 | CD1a-phosphatidylglycerol binary structure | x-ray diffraction | A | NAG, MW9 | — |
| P06126 | AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD1A (P06126) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- SO4 · Sulfate ion · in 3 records
- FO4 · sphingomyelin · in 2 records
- WGR · dideoxymycobactin-838 · in 2 records
- WU7 · (4S,7S,17Z)-4-hydroxy-7-[(1S,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphahexacos-17-en-1-aminium · in 2 records
- WUA · (4R,7S)-4-hydroxy-7-[(1S,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphadotriacontan-1-aminium · in 2 records
- 6F8 · 3-[(8Z,11Z)-pentadeca-8,11-dien-1-yl]benzene-1,2-diol · in 1 record
- CIS · (15Z)-N-((1S,2R,3E)-2-hydroxy-1-{[(3-O-sulfo-beta-D-galactopyranosyl)oxy]methyl}heptadec-3-enyl)tetracos-15-enamide · in 1 record
- MW9 · (21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate · in 1 record
Experiment against prediction
- 4X6F chain A against the predicted model P06126: TM-score 0.97, RMSD 1.11 Å
- 4X6F chain A against the predicted model P06126: TM-score 0.97, RMSD 1.11 Å
- 5J1A chain A against the predicted model P06126: TM-score 0.97, RMSD 1.29 Å
- 5J1A chain A against the predicted model P06126: TM-score 0.97, RMSD 1.29 Å
- 1ONQ chain A against the predicted model P06126: TM-score 0.97, RMSD 1.05 Å
- 1ONQ chain A against the predicted model P06126: TM-score 0.97, RMSD 1.05 Å
- 1ONQ chain C against the predicted model P06126: TM-score 0.97, RMSD 1.05 Å
- 1ONQ chain C against the predicted model P06126: TM-score 0.97, RMSD 1.05 Å
- 7RYN chain A against the predicted model P06126: TM-score 0.97, RMSD 1.08 Å
- 7RYM chain A against the predicted model P06126: TM-score 0.97, RMSD 1.08 Å
Elsewhere
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