UniProt P05981
Serine protease hepsin (P05981)
Serine protease hepsin (UniProt P05981), EC 3.4.21.106: 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05981
- Protein
- Serine protease hepsin
- EC
- 3.4.21.106
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
13 records of P05981 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1O5E | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial… | x-ray diffraction | L, H | — | — |
| 1O5E | Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial… | x-ray diffraction | L, H | — | — |
| 1O5F | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial… | x-ray diffraction | L, H | — | — |
| 1O5F | Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial… | x-ray diffraction | L, H | — | — |
| 1P57 | Extracellular domain of human hepsin | x-ray diffraction | A, B | — | — |
| 1P57 | Extracellular domain of human hepsin | x-ray diffraction | A, B | — | — |
| 1Z8G | Crystal structure of the extracellular region of the transmembrane serine protease hepsin with… | x-ray diffraction | A | — | — |
| 1Z8G | Crystal structure of the extracellular region of the transmembrane serine protease hepsin with… | x-ray diffraction | A | — | — |
| 3T2N | Human hepsin protease in complex with the Fab fragment of an inhibitory antibody | x-ray diffraction | A, B | — | — |
| 3T2N | Human hepsin protease in complex with the Fab fragment of an inhibitory antibody | x-ray diffraction | A, B | — | — |
| 5CE1 | Crystal Structure of Serine protease Hepsin in complex with Inhibitor | x-ray diffraction | A | 50K | 2 (best 0.42) |
| 5CE1 | Crystal structure of serine protease hepsin in complex with inhibitor | x-ray diffraction | A | — | — |
| P05981 | AlphaFold monomer V2.0 prediction for serine protease hepsin (P05981) | predicted | A | — | 4 (best 0.52) |
Ligands
- 50K · 2-[6-(1-hydroxycyclohexyl)pyridin-2-yl]-1H-indole-5-carboximidamide · in 1 record
Experiment against prediction
- 1Z8G chain A against the predicted model P05981: TM-score 0.99, RMSD 0.57 Å
- 1Z8G chain A against the predicted model P05981: TM-score 0.99, RMSD 0.57 Å
- 1O5F chain L against the predicted model P05981: TM-score 0.99, RMSD 0.51 Å
- 1O5F chain L against the predicted model P05981: TM-score 0.99, RMSD 0.51 Å
- 5CE1 chain A against the predicted model P05981: TM-score 0.99, RMSD 0.69 Å
- 5CE1 chain A against the predicted model P05981: TM-score 0.99, RMSD 0.69 Å
- 1P57 chain A against the predicted model P05981: TM-score 0.99, RMSD 0.50 Å
- 1P57 chain A against the predicted model P05981: TM-score 0.99, RMSD 0.50 Å
- 1P57 chain B against the predicted model P05981: TM-score 0.99, RMSD 0.60 Å
- 1P57 chain B against the predicted model P05981: TM-score 0.99, RMSD 0.60 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.