UniProt P05373
5-aminolaevulinic acid dehydratase (P05373)
5-aminolaevulinic acid dehydratase (UniProt P05373), EC 4.2.1.24: 24 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P05373
- Protein
- 5-aminolaevulinic acid dehydratase
- EC
- 4.2.1.24
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 38 · 7 records with a druggable one
Structures
25 records of P05373 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AW5 | 5-aminolevulinate dehydratase from saccharomyces cerevisiae | x-ray diffraction | A | ZN | 2 (best 0.55) |
| 1AW5 | 5-aminolevulinate dehydratase from saccharomyces cerevisiae | x-ray diffraction | A | — | — |
| 1EB3 | Yeast 5-aminolaevulinic acid dehydratase 4,7-dioxosebacic acid complex | x-ray diffraction | A | DSB, ZN | 3 (best 0.33) |
| 1EB3 | Yeast 5-aminolaevulinic acid dehydratase 4,7-dioxosebacic acid complex | x-ray diffraction | A | — | — |
| 1GJP | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with 4-oxosebacic acid | x-ray diffraction | A | 4OX, ZN | 4 (best 0.66) |
| 1GJP | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with 4-oxosebacic acid | x-ray diffraction | A | — | — |
| 1H7N | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid at 1.6 a… | x-ray diffraction | A | SHF, ZN | 3 (best 0.35) |
| 1H7N | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid at 1.6 a… | x-ray diffraction | A | — | — |
| 1H7O | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with 5-aminolaevulinic acid at 1.7… | x-ray diffraction | A | DAV, ZN | 3 (best 0.36) |
| 1H7O | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with 5-aminolaevulinic acid at 1.7… | x-ray diffraction | A | — | — |
| 1H7P | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with 4-keto-5-amino-hexanoic (kah)… | x-ray diffraction | A | KAH, ZN | 4 (best 0.65) |
| 1H7P | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with 4-keto-5-amino-hexanoic (kah)… | x-ray diffraction | A | — | — |
| 1H7R | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with succinylacetone at 2.0 a… | x-ray diffraction | A | SHU, ZN | 3 (best 0.76) |
| 1H7R | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with succinylacetone at 2.0 a… | x-ray diffraction | A | — | — |
| 1OHL | Yeast 5-aminolaevulinic acid dehydratase putative cyclic reaction intermediate complex | x-ray diffraction | A | ZN, PBG | 3 (best 0.32) |
| 1OHL | Yeast 5-aminolaevulinic acid dehydratase putative cyclic reaction intermediate complex | x-ray diffraction | A | — | — |
| 1QML | Hg complex of yeast 5-aminolaevulinic acid dehydratase | x-ray diffraction | A | HG | 3 (best 0.58) |
| 1QML | Hg complex of yeast 5-aminolaevulinic acid dehydratase | x-ray diffraction | A | — | — |
| 1QNV | yeast 5-aminolaevulinic acid dehydratase Lead (Pb) complex | x-ray diffraction | A | PB | 2 (best 0.56) |
| 1QNV | Yeast 5-aminolaevulinic acid dehydratase lead (pb) complex | x-ray diffraction | A | — | — |
| 1W31 | Yeast 5-aminolaevulinic acid dehydratase 5-hydroxylaevulinic acid complex | x-ray diffraction | A | SHO, ZN | 3 (best 0.63) |
| 1W31 | Yeast 5-aminolaevulinic acid dehydratase 5-hydroxylaevulinic acid complex | x-ray diffraction | A | — | — |
| 1YLV | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid | x-ray diffraction | A | ZN, SHF | 3 (best 0.36) |
| 1YLV | Schiff-base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid | x-ray diffraction | A | — | — |
| P05373 | AlphaFold monomer V2.0 prediction for delta-aminolevulinic acid dehydratase (P05373) | predicted | A | — | 2 (best 0.38) |
Ligands
- ZN · Zinc ion · in 10 records
- SHF · Laevulinic acid · in 2 records
- 4OX · 4-oxodecanedioic acid · in 1 record
- DAV · Delta-amino valeric acid · in 1 record
- DSB · 4,7-dioxosebacic acid · in 1 record
- HG · Mercury (II) ion · in 1 record
- KAH · 5-amino-4-hydroxyhexanoic acid · in 1 record
- PB · Lead (II) ion · in 1 record
- PBG · 3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid · in 1 record
- SHO · 5-hydroxylaevulinic acid · in 1 record
- SHU · 4,6-dioxoheptanoic acid · in 1 record
Experiment against prediction
- 1H7N chain A against the predicted model P05373: TM-score 0.98, RMSD 1.01 Å
- 1H7N chain A against the predicted model P05373: TM-score 0.98, RMSD 1.01 Å
- 1OHL chain A against the predicted model P05373: TM-score 0.98, RMSD 1.04 Å
- 1OHL chain A against the predicted model P05373: TM-score 0.98, RMSD 1.04 Å
- 1H7P chain A against the predicted model P05373: TM-score 0.98, RMSD 1.03 Å
- 1H7P chain A against the predicted model P05373: TM-score 0.98, RMSD 1.03 Å
- 1YLV chain A against the predicted model P05373: TM-score 0.98, RMSD 1.05 Å
- 1YLV chain A against the predicted model P05373: TM-score 0.98, RMSD 1.05 Å
- 1H7O chain A against the predicted model P05373: TM-score 0.98, RMSD 1.07 Å
- 1H7O chain A against the predicted model P05373: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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