UniProt P04920
Anion exchange protein 2 (P04920)
Anion exchange protein 2 (UniProt P04920): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 127 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04920
- Protein
- Anion exchange protein 2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 127 · 8 records with a druggable one
Structures
9 records of P04920 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GV8 | The cryo-EM structure of hAE2 with DIDS | electron microscopy | A, B | 4KU | 15 (best 0.78) |
| 8GV9 | The cryo-EM structure of hAE2 with chloride ion | electron microscopy | A, B | CL | 18 (best 0.78) |
| 8GVA | The intermediate structure of hAE2 in basic pH | electron microscopy | A, B | — | 17 (best 0.78) |
| 8GVC | The cryo-EM structure of hAE2 with bicarbonate | electron microscopy | A, B | BCT | 15 (best 0.77) |
| 8GVF | The outward-facing structure of hAE2 in basic pH | electron microscopy | A, B | — | 15 (best 0.77) |
| 8GVH | Human AE2 in acidic KNO3 | electron microscopy | A, B | Y01 | 20 (best 0.77) |
| 8JNI | Structure of AE2 in complex with PIP2 | electron microscopy | B, A | CL, PT5 | 10 (best 0.78) |
| 8JNJ | Structure of R932A/K1147A/H1148A mutant AE2 | electron microscopy | A, B | — | 17 (best 0.77) |
| P04920 | AlphaFold monomer V2.0 prediction for anion exchange protein 2 (P04920) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
- 4KU · 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid} · in 1 record
- BCT · Bicarbonate ion · in 1 record
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8GVF chain B against the predicted model P04920: TM-score 0.96, RMSD 1.70 Å
- 8GVC chain B against the predicted model P04920: TM-score 0.96, RMSD 1.75 Å
- 8GVC chain A against the predicted model P04920: TM-score 0.96, RMSD 1.80 Å
- 8GVF chain A against the predicted model P04920: TM-score 0.96, RMSD 1.80 Å
- 8GV8 chain B against the predicted model P04920: TM-score 0.96, RMSD 1.90 Å
- 8GV8 chain A against the predicted model P04920: TM-score 0.95, RMSD 1.94 Å
- 8JNI chain B against the predicted model P04920: TM-score 0.91, RMSD 2.55 Å
- 8JNI chain A against the predicted model P04920: TM-score 0.91, RMSD 2.55 Å
- 8GVA chain A against the predicted model P04920: TM-score 0.89, RMSD 2.90 Å
- 8GVA chain B against the predicted model P04920: TM-score 0.89, RMSD 2.90 Å
Elsewhere
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