UniProt P04912
Histone H2A.2 (P04912)
Histone H2A.2 (UniProt P04912): 8 experimental structures and 1 predicted model on GenesisL1, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04912
- Protein
- Histone H2A.2
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 14 · 3 records with a druggable one
Structures
9 records of P04912 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JJN | Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome | x-ray diffraction | C, G | — | — |
| 4JJN | Crystal structure of heterochromatin protein SIR3 in complex with a silenced yeast nucleosome | x-ray diffraction | C, G | — | — |
| 4KUD | Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast… | x-ray diffraction | C, G | — | — |
| 4KUD | Crystal structure of N-terminal acetylated SIR3 bah domain D205N mutant in complex with yeast… | x-ray diffraction | C, G | — | — |
| 7E9C | Cryo-EM structure of the 1:1 Orc1 BAH domain in complex with nucleosome | electron microscopy | C, G | — | 12 (best 0.76) |
| 8F1E | Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B | electron microscopy | B | — | — |
| 8QKU | SWR1-nucleosome complex in configuration 1 | electron microscopy | E, F | — | 1 (best 0.77) |
| 8QKV | SWR1-nucleosome complex in configuration 2 | electron microscopy | F, E | — | 1 (best 0.77) |
| P04912 | AlphaFold monomer V2.0 prediction for histone H2A.2 (P04912) | predicted | A | — | — |
Experiment against prediction
- 4JJN chain C against the predicted model P04912: TM-score 0.96, RMSD 0.86 Å
- 4JJN chain C against the predicted model P04912: TM-score 0.96, RMSD 0.86 Å
- 4JJN chain G against the predicted model P04912: TM-score 0.96, RMSD 0.89 Å
- 4JJN chain G against the predicted model P04912: TM-score 0.96, RMSD 0.89 Å
- 4KUD chain C against the predicted model P04912: TM-score 0.96, RMSD 0.84 Å
- 4KUD chain C against the predicted model P04912: TM-score 0.96, RMSD 0.84 Å
- 4KUD chain G against the predicted model P04912: TM-score 0.96, RMSD 0.86 Å
- 4KUD chain G against the predicted model P04912: TM-score 0.96, RMSD 0.86 Å
- 7E9C chain G against the predicted model P04912: TM-score 0.93, RMSD 1.10 Å
- 8QKU chain E against the predicted model P04912: TM-score 0.92, RMSD 1.25 Å
Elsewhere
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