UniProt P04789
Triosephosphate isomerase, glycosomal (P04789)
Triosephosphate isomerase, glycosomal (UniProt P04789), EC 5.3.1.1: 92 experimental structures and 3 predicted models on GenesisL1, 5 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P04789
- Protein
- Triosephosphate isomerase, glycosomal
- EC
- 5.3.1.1
- Experimental structures
- 92
- Predicted models
- 3
- Ligands
- 5
- Pockets
- 8 · 1 record with a druggable one
Structures
95 records of P04789 in the MolNFT archive: 92 experimental, 3 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AG1 | Monohydrogen phosphate binding to trypanosomal triosephosphate isomerase | x-ray diffraction | O, T | — | — |
| 1AG1 | Monohydrogen phosphate binding to trypanosomal triosephosphate isomerase | x-ray diffraction | O, T | — | — |
| 1DKW | Crystal structure of triose-phosphate isomerase with modified substrate binding site | x-ray diffraction | A, B | — | — |
| 1DKW | Crystal structure of triose-phosphate isomerase with modified substrate binding site | x-ray diffraction | A, B | — | — |
| 1IIG | Structure of trypanosoma brucei brucei triosephosphate isomerase complexed with… | x-ray diffraction | A, B | — | — |
| 1IIG | Structure of trypanosoma brucei brucei triosephosphate isomerase complexed with… | x-ray diffraction | A, B | — | — |
| 1IIH | Structure of trypanosoma brucei brucei triosephosphate isomerase complexed with 3-phosphoglycerate | x-ray diffraction | A, B | — | — |
| 1IIH | Structure of trypanosoma brucei brucei triosephosphate isomerase complexed with 3-phosphoglycerate | x-ray diffraction | A, B | — | — |
| 1KV5 | Structure of Trypanosoma brucei brucei TIM with the salt-bridge-forming residue Arg191 mutated to… | x-ray diffraction | A, B | — | — |
| 1KV5 | Structure of trypanosoma brucei brucei tim with the salt-bridge- forming residue ARG191 mutated to… | x-ray diffraction | A, B | — | — |
| 1ML1 | Protein engineering with monomeric triosephosphate isomerase: the modelling and structure… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1ML1 | Protein engineering with monomeric triosephosphate isomerase: the modelling and structure… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1MSS | Large scale structural rearrangements of the front loops in monomerised triosephosphate isomerase… | x-ray diffraction | A, B | — | — |
| 1MSS | Large scale structural rearrangements of the front loops in monomerised triosephosphate isomerase… | x-ray diffraction | A, B | — | — |
| 1TPD | Structures of the open" and "closed" state of trypanosomal triosephosphate isomerase | x-ray diffraction | A, B | — | — |
| 1TPD | Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed… | x-ray diffraction | A, B | — | — |
| 1TPE | Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in… | x-ray diffraction | A | — | — |
| 1TPE | Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in… | x-ray diffraction | A | — | — |
| 1TPF | Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in… | x-ray diffraction | A, B | — | — |
| 1TPF | Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in… | x-ray diffraction | A, B | — | — |
| 1TRD | The influence of crystal packing on crystallographic binding studies: a new crystal form of… | x-ray diffraction | A, B | — | — |
| 1TRD | The influence of crystal packing on crystallographic binding studies: a new crystal form of… | x-ray diffraction | A, B | — | — |
| 1TRI | The crystal structure of an engineered monomeric triosephosphate isomerase, monotim: the correct… | x-ray diffraction | A | — | — |
| 1TRI | The crystal structure of an engineered monomeric triosephosphate isomerase, monotim: the correct… | x-ray diffraction | A | — | — |
| 1TSI | Structure of the complex between trypanosomal triosephosphate isomerase and… | x-ray diffraction | A, B | — | — |
| 1TSI | Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono… | x-ray diffraction | A, B | — | — |
| 1TTI | Three new crystal structures of point mutation variants of monotim: conformational flexibility of… | x-ray diffraction | A | — | — |
| 1TTI | Three new crystal structures of point mutation variants of monotim: conformational flexibility of… | x-ray diffraction | A | — | — |
| 1TTJ | Three new crystal structures of point mutation variants of monotim: conformational flexibility of… | x-ray diffraction | A | — | — |
| 1TTJ | Three new crystal structures of point mutation variants of monotim: conformational flexibility of… | x-ray diffraction | A | — | — |
| 2J24 | The functional role of the conserved active site proline of triosephosphate isomerase | x-ray diffraction | A, B | — | — |
| 2J24 | The functional role of the conserved active site proline of triosephosphate isomerase | x-ray diffraction | A, B | — | — |
| 2J27 | The functional role of the conserved active site proline of triosephosphate isomerase. | x-ray diffraction | A, B | — | — |
| 2J27 | The functional role of the conserved active site proline of triosephosphate isomerase | x-ray diffraction | A, B | — | — |
| 2V0T | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2V0T | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2V2C | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A | — | — |
| 2V2C | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A | — | — |
| 2V2D | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A | — | — |
| 2V2D | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A | — | — |
| 2V2H | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A, B, C | — | — |
| 2V2H | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase… | x-ray diffraction | A, B, C | — | — |
| 2V5L | Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: as Observed in a… | x-ray diffraction | A, B | — | — |
| 2V5L | Structures of the open and closed state of trypanosomal triosephosphate isomerase: as observed in a… | x-ray diffraction | A, B | — | — |
| 2VEI | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance… | x-ray diffraction | A, B, C | — | — |
| 2VEI | Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance… | x-ray diffraction | A, B, C | — | — |
| 2VEK | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEK | Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEL | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEL | Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEM | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEM | Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEN | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance… | x-ray diffraction | A, B | — | — |
| 2VEN | Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance… | x-ray diffraction | A, B | — | — |
| 2WSQ | MonoTIM mutant RMM0-1, dimeric form. | x-ray diffraction | A, B, C, D | — | — |
| 2WSQ | Monotim mutant RMM0-1, dimeric form. | x-ray diffraction | A, B, C, D | — | — |
| 2WSR | Monotim mutant RMM0-1, monomeric form. | x-ray diffraction | A | — | — |
| 2WSR | Monotim mutant RMM0-1, monomeric form. | x-ray diffraction | A | — | — |
| 2X16 | Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase | x-ray diffraction | A, B | — | — |
| 2X16 | Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase | x-ray diffraction | A, B | — | — |
35 records more on the page itself.
Ligands
Experiment against prediction
- 1AG1 chain O against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1AG1 chain O against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1AG1 chain O against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1AG1 chain O against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 6TIM chain A against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 6TIM chain A against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1IIH chain A against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1IIH chain A against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1IIH chain A against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
- 1IIH chain A against the predicted model 4TIM: TM-score 1.00, RMSD 0.17 Å
Elsewhere
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