UniProt P04406
Glyceraldehyde-3-phosphate dehydrogenase (P04406)
Glyceraldehyde-3-phosphate dehydrogenase (UniProt P04406), EC 1.2.1.12, 2.6.99.-: 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 90 pockets. Binding sites, druggability and experiment against…
- UniProt
- P04406
- Protein
- Glyceraldehyde-3-phosphate dehydrogenase
- EC
- 1.2.1.12, 2.6.99.-
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 90 · 8 records with a druggable one
Structures
23 records of P04406 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U8F | Crystal Structure Of Human Placental Glyceraldehyde-3-Phosphate Dehydrogenase At 1.75 Resolution | x-ray diffraction | O, P, Q, R | — | — |
| 1U8F | Crystal structure of human placental glyceraldehyde-3- phosphate dehydrogenase at 1.75 resolution | x-ray diffraction | O, P, Q, R | — | — |
| 1ZNQ | Crystal Structure of Human Liver GAPDH | x-ray diffraction | O, P, R, Q | — | — |
| 1ZNQ | Crystal structure of human liver GAPDH | x-ray diffraction | O, P, R, Q | — | — |
| 4WNC | Crystal structure of human wild-type GAPDH at 1.99 angstroms resolution | x-ray diffraction | O, A, B, C, D, E, F, G | — | — |
| 4WNC | Crystal structure of human wild-type GAPDH at 1.99 ångströms resolution | x-ray diffraction | O, A, B, C, D, E, F, G | — | — |
| 4WNI | Crystal structure of the T229K mutant of human GAPDH at 2.3 angstroems resolution | x-ray diffraction | O, A, B, C | — | — |
| 6ADE | Crystal structure of phosphorylated mutant of glyceraldehyde 3-phosphate dehydrogenase from human… | x-ray diffraction | A, B, C | NAD | 6 (best 0.60) |
| 6ADE | Crystal structure of phosphorylated mutant of glyceraldehyde 3- phosphate dehydrogenase from human… | x-ray diffraction | A, B, C | NAD | — |
| 6IQ6 | Crystal structure of GAPDH | x-ray diffraction | A, B, C, D, E, F, G, H | AW9 | — |
| 6M61 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with inhibitor heptelidic acid | x-ray diffraction | O, Q, P, R | ZN, F4F, NAD | — |
| 6YND | GAPDH purified from the supernatant of HEK293F cells: crystal form 1 of 4. | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.78) |
| 6YND | GAPDH purified from the supernatant of HEK293F cells: crystal form 1 of 4. | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6YNE | GAPDH purified from the supernatant of HEK293F cells: crystal form 2 of 4. | x-ray diffraction | A, B, C, D | — | — |
| 6YNF | GAPDH purified from the supernatant of HEK293F cells: crystal form 3 of 4. | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6YNH | GAPDH purified from the supernatant of HEK293F cells: crystal form 4 of 4 | x-ray diffraction | B, D, F, G | — | — |
| 8DNS | Human Brain Glyceraldehyde 3-phosphate dehydrogenase | electron microscopy | O, P, Q, R | — | 9 (best 0.75) |
| 8G12 | CryoEM structure of nuclear GAPDH under 8h Oxidative Stress | electron microscopy | A, B, C, D | — | 15 (best 0.81) |
| 8G15 | CryoEM structure of nuclear GAPDH under 24h Oxidative Stress | electron microscopy | A, B, C, D | — | 10 (best 0.82) |
| 8G16 | CryoEM structure of cytoplasmic GAPDH under 24h Oxidative Stress | electron microscopy | A, B, C, D | — | 11 (best 0.77) |
| 8G17 | CryoEM structure of wild-type GAPDH | electron microscopy | A, B, C, D | — | 11 (best 0.75) |
| 8P5F | Human wild-type GAPDH,orthorhombic form | x-ray diffraction | AAA, DDD, EEE, GGG | NAD, ZN | 8 (best 0.77) |
| P04406 | AlphaFold monomer V2.0 prediction for glyceraldehyde-3-phosphate dehydrogenase (P04406) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8P5F chain DDD against the predicted model P04406: TM-score 1.00, RMSD 0.27 Å
- 1U8F chain P against the predicted model P04406: TM-score 1.00, RMSD 0.29 Å
- 1U8F chain P against the predicted model P04406: TM-score 1.00, RMSD 0.29 Å
- 4WNC chain A against the predicted model P04406: TM-score 1.00, RMSD 0.29 Å
- 4WNC chain A against the predicted model P04406: TM-score 1.00, RMSD 0.29 Å
- 4WNC chain B against the predicted model P04406: TM-score 1.00, RMSD 0.29 Å
- 4WNC chain B against the predicted model P04406: TM-score 1.00, RMSD 0.29 Å
- 4WNC chain D against the predicted model P04406: TM-score 1.00, RMSD 0.30 Å
- 4WNC chain D against the predicted model P04406: TM-score 1.00, RMSD 0.30 Å
- 4WNC chain O against the predicted model P04406: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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