UniProt P04070
Vitamin K-dependent protein C heavy chain (P04070)
Vitamin K-dependent protein C heavy chain (UniProt P04070), EC 3.4.21.69: 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P04070
- Protein
- Vitamin K-dependent protein C heavy chain
- EC
- 3.4.21.69
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 36 · 5 records with a druggable one
Structures
17 records of P04070 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AUT | Human activated protein C | x-ray diffraction | C, L | — | — |
| 1AUT | Human activated protein C | x-ray diffraction | C, L | — | — |
| 1LQV | Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex… | x-ray diffraction | C, D | — | — |
| 1LQV | Crystal structure of the endothelial protein C receptor with phospholipid in the groove in complex… | x-ray diffraction | C, D | — | — |
| 3F6U | Crystal structure of human Activated Protein C (APC) complexed with PPACK | x-ray diffraction | H, L | — | — |
| 3F6U | Crystal structure of human activated protein C (apc) complexed with ppack | x-ray diffraction | H, L | — | — |
| 3JTC | Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of… | x-ray diffraction | C, D | — | — |
| 3JTC | Importance of MG2+ in the CA2+-dependent folding of the gamma- carboxyglutamic acid domains of… | x-ray diffraction | C, D | — | — |
| 4DT7 | Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C | x-ray diffraction | E, F | — | — |
| 4DT7 | Crystal structure of thrombin bound to the activation domain qedqvdprlidgkmtrrgds of protein C | x-ray diffraction | E, F | — | — |
| 6M3B | hAPC-c25k23 Fab complex | x-ray diffraction | A, D | NAG | 4 (best 0.58) |
| 6M3B | Hapc-C25K23 Fab complex | x-ray diffraction | A, D | NAG | — |
| 6M3C | hAPC-h1573 Fab complex | x-ray diffraction | A, B, C, D, G, I | — | 16 (best 0.69) |
| 6M3C | Hapc-H1573 Fab complex | x-ray diffraction | A, B, C, D, G, I | — | — |
| 8JRU | Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | electron microscopy | R | PIO | 5 (best 0.75) |
| 8JRV | Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | electron microscopy | R | PIO | 6 (best 0.78) |
| P04070 | AlphaFold monomer V2.0 prediction for vitamin K-dependent protein C (P04070) | predicted | A | — | 5 (best 0.67) |
Ligands
Experiment against prediction
- 6M3B chain A against the predicted model P04070: TM-score 0.98, RMSD 0.92 Å
- 6M3B chain A against the predicted model P04070: TM-score 0.98, RMSD 0.92 Å
- 6M3C chain A against the predicted model P04070: TM-score 0.96, RMSD 1.50 Å
- 6M3C chain A against the predicted model P04070: TM-score 0.96, RMSD 1.50 Å
- 1AUT chain C against the predicted model P04070: TM-score 0.94, RMSD 1.43 Å
- 1AUT chain C against the predicted model P04070: TM-score 0.94, RMSD 1.43 Å
- 3F6U chain H against the predicted model P04070: TM-score 0.94, RMSD 1.46 Å
- 3F6U chain H against the predicted model P04070: TM-score 0.94, RMSD 1.46 Å
- 6M3B chain D against the predicted model P04070: TM-score 0.94, RMSD 0.97 Å
- 6M3B chain D against the predicted model P04070: TM-score 0.94, RMSD 0.97 Å
Elsewhere
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