UniProt P01854
Ig epsilon chain C region (P01854)
Ig epsilon chain C region (UniProt P01854): 65 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 183 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01854
- Protein
- Ig epsilon chain C region
- Experimental structures
- 65
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 183 · 18 records with a druggable one
Structures
66 records of P01854 in the MolNFT archive: 65 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F6A | Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha) | x-ray diffraction | B, D | — | — |
| 1F6A | Structure of the human IgE-Fc bound to its high affinity receptor FC(EPSILON)RI(ALPHA) | x-ray diffraction | B, D | — | — |
| 1FP5 | Crystal structure analysis of the human IgE-Fc CEPSILON3-CEPSILON4 fragment. | x-ray diffraction | A | — | — |
| 1FP5 | Crystal structure analysis of the human IgE-Fc CEPSILON3- CEPSILON4 fragment. | x-ray diffraction | A | — | — |
| 1G84 | The solution structure of the C EPSILON2 domain from IgE | solution nmr | A | — | — |
| 1G84 | The solution structure of the C EPSILON2 domain from IgE | solution nmr | A | — | — |
| 2WQR | The high resolution crystal structure of IgE Fc | x-ray diffraction | A, B | — | — |
| 2WQR | The high resolution crystal structure of IgE Fc | x-ray diffraction | A, B | — | — |
| 2Y7Q | The high-affinity complex between IgE and its receptor Fc epsilon ri | x-ray diffraction | B, D | — | — |
| 2Y7Q | The high-affinity complex between IgE and its receptor Fc epsilon ri | x-ray diffraction | B, D | — | — |
| 3H9Y | Crystal structure of the IgE-Fc3-4 domains | x-ray diffraction | A, B, E | — | — |
| 3H9Y | Crystal structure of the IgE-FC3-4 domains | x-ray diffraction | A, B, E | — | — |
| 3H9Z | Crystal structure of the IgE-Fc3-4 domains | x-ray diffraction | A, B, C, D | — | — |
| 3H9Z | Crystal structure of the IgE-FC3-4 domains | x-ray diffraction | A, B, C, D | — | — |
| 3HA0 | Crystal structure of the IgE-Fc3-4 domains | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HA0 | Crystal structure of the IgE-FC3-4 domains | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4EZM | Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4EZM | Crystal structure of the human IgE-FC(EPSILON)3-4 bound to its B cell receptor DERCD23 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4GKO | Crystal structure of the calcium2+-bound human IgE-Fc(epsilon)3-4 bound to its B cell receptor… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4GKO | Crystal structure of the CALCIUM2+-bound human IgE-FC(EPSILON)3-4 bound to its B cell receptor… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4GRG | Crystal structure of IgE complexed with E2_79, an anti-IgE inhibitor | x-ray diffraction | C, D | — | — |
| 4GRG | Crystal structure of IgE complexed with E2_79, an anti-IgE inhibitor | x-ray diffraction | C, D | — | — |
| 4GT7 | An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, non-receptor binding… | x-ray diffraction | A, B, C, D | — | — |
| 4GT7 | An engineered disulfide bond reversibly traps the IgE-FC3-4 in a closed, non-receptor binding… | x-ray diffraction | A, B, C, D | — | — |
| 4J4P | The complex of human IgE-Fc with two bound Fab fragments | x-ray diffraction | A, B | — | — |
| 4J4P | The complex of human IgE-Fc with two bound Fab fragments | x-ray diffraction | A, B | — | — |
| 4KI1 | Primitive triclinic crystal form of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor… | x-ray diffraction | A, B, C, D | — | — |
| 4KI1 | Primitive triclinic crystal form of the human IgE-FC(EPSILON)3-4 bound to its B cell receptor… | x-ray diffraction | A, B, C, D | — | — |
| 5ANM | Crystal structure of IgE Fc in complex with a neutralizing antibody | x-ray diffraction | E, F, G | NAG, BMA, MAN | 11 (best 0.57) |
| 5ANM | Crystal structure of IgE Fc in complex with a neutralizing antibody | x-ray diffraction | E, F, G | — | — |
| 5HYS | Structure of IgE complexed with omalizumab | x-ray diffraction | G, I, J, K | NAG, BMA, MAN, SO4 | 12 (best 0.70) |
| 5HYS | Structure of IgE complexed with omalizumab | x-ray diffraction | G, I, J, K | — | — |
| 5LGJ | The crystal structure of IgE Fc mutant - P333C | x-ray diffraction | A, B | NAG, BMA, MAN, SO4 | 6 (best 0.77) |
| 5LGJ | The crystal structure of IgE Fc mutant - P333C | x-ray diffraction | A, B | NAG, BMA, MAN, SO4 | — |
| 5LGK | Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23 | x-ray diffraction | A, B, C, D | NAG, BMA | 20 (best 0.79) |
| 5LGK | Crystal structure of the human IgE-Fc bound to its B cell receptor DERCD23 | x-ray diffraction | A, B, C, D | NAG, BMA | — |
| 5MOI | Crystal structure of human IgE-Fc epsilon 3-4 | x-ray diffraction | A, B, C, D, E, F | NAG, BMA, MAN, PO4 | 11 (best 0.81) |
| 5MOI | Crystal structure of human IgE-Fc epsilon 3-4 | x-ray diffraction | A, B, C, D, E, F | NAG, BMA, MAN, PO4 | — |
| 5MOJ | Crystal structure of IgE-Fc epsilon 3-4 | x-ray diffraction | A, B | NAG, BMA, MAN, SO4 | 5 (best 0.57) |
| 5MOJ | Crystal structure of IgE-Fc epsilon 3-4 | x-ray diffraction | A, B | NAG, MAN, BMA, SO4 | — |
| 5MOK | Crystal structure of human IgE-Fc epsilon 3-4 | x-ray diffraction | A, B, C, D | NAG, BMA, MAN | — |
| 5MOK | Crystal structure of human IgE-Fc epsilon 3-4 | x-ray diffraction | A, B, C, D | NAG, BMA, MAN | — |
| 5MOL | Human IgE-Fc crystal structure | x-ray diffraction | A, B | NAG, BMA, MAN, AE3 | 12 (best 0.67) |
| 5MOL | Human IgE-Fc crystal structure | x-ray diffraction | A, B | NAG, BMA, MAN, AE3 | — |
| 5NQW | IgE-Fc in complex with single domain antibody 026 | x-ray diffraction | A, B | NAG, BMA, MAN | — |
| 5NQW | IgE-Fc in complex with single domain antibody 026 | x-ray diffraction | A, B | NAG, BMA, MAN | — |
| 6EYO | Structure of extended IgE-Fc in complex with two anti-IgE Fabs | x-ray diffraction | A, B | NAG, BMA, MAN | 8 (best 0.76) |
| 6EYO | Structure of extended IgE-Fc in complex with two anti-IgE fabs | x-ray diffraction | A, B | NAG, BMA, MAN | — |
| 6UQR | Complex of IgE and Ligelizumab | x-ray diffraction | B, D | NAG, BMA, MAN | 8 (best 0.63) |
| 6UQR | Complex of IgE and ligelizumab | x-ray diffraction | B, D | NAG, BMA, MAN | — |
| 7MXI | IgE-Fc in complex with DARPins E2_79 and E3_53 | x-ray diffraction | A, B | NAG, BMA, FUC | 12 (best 0.59) |
| 7MXI | IgE-Fc in complex with darpins E2_79 and E3_53 | x-ray diffraction | A, B | NAG, BMA, FUC | — |
| 7SHT | Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant | electron microscopy | B, D | NAG, MAN | 11 (best 0.81) |
| 7SHT | Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant | electron microscopy | B, D | NAG, MAN | — |
| 7SHU | IgE-Fc in complex with omalizumab variant C02 | x-ray diffraction | B, A | NAG, BMA, PO4 | 6 (best 0.66) |
| 7SHU | IgE-Fc in complex with omalizumab variant C02 | x-ray diffraction | B, A | NAG, BMA, PO4 | — |
| 7SHY | IgE-Fc in complex with omalizumab scFv | x-ray diffraction | A, G, H, B | NAG, BMA, MAN, FUC | 13 (best 0.69) |
| 7SHY | IgE-Fc in complex with omalizumab scfv | x-ray diffraction | A, G, H, B | NAG, BMA, MAN, FUC | — |
| 7SHZ | IgE-Fc in complex with HAE | x-ray diffraction | B, A, H, G | NAG, BMA, MAN | 11 (best 0.68) |
| 7SHZ | IgE-Fc in complex with hae | x-ray diffraction | B, A, H, G | NAG, BMA, MAN | — |
6 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 35 records
- BMA · beta-D-mannopyranose · in 33 records
- MAN · alpha-D-mannopyranose · in 28 records
- SO4 · Sulfate ion · in 5 records
- FUC · alpha-L-fucopyranose · in 4 records
- PO4 · Phosphate ion · in 4 records
- AE3 · 2-(2-ethoxyethoxy)ethanol · in 2 records
Experiment against prediction
- 7SHZ chain G against the predicted model P01854: TM-score 0.97, RMSD 1.06 Å
- 7SHZ chain G against the predicted model P01854: TM-score 0.97, RMSD 1.06 Å
- 5MOK chain B against the predicted model P01854: TM-score 0.97, RMSD 1.08 Å
- 5MOK chain B against the predicted model P01854: TM-score 0.97, RMSD 1.08 Å
- 7SHY chain H against the predicted model P01854: TM-score 0.96, RMSD 1.11 Å
- 7SHY chain H against the predicted model P01854: TM-score 0.96, RMSD 1.11 Å
- 5MOI chain A against the predicted model P01854: TM-score 0.96, RMSD 1.08 Å
- 5MOI chain A against the predicted model P01854: TM-score 0.96, RMSD 1.08 Å
- 5MOI chain E against the predicted model P01854: TM-score 0.96, RMSD 1.15 Å
- 5MOI chain E against the predicted model P01854: TM-score 0.96, RMSD 1.15 Å
Elsewhere
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