UniProt P01270
Parathyroid hormone (P01270)
Parathyroid hormone (UniProt P01270): 37 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01270
- Protein
- Parathyroid hormone
- Experimental structures
- 37
- Predicted models
- 1
- Pockets
- 6 · 2 records with a druggable one
Structures
38 records of P01270 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BWX | The solution structure of human parathyroid hormone fragment 1-39, NMR, 10 structures | solution nmr | A | — | — |
| 1BWX | The solution structure of human parathyroid hormone fragment 1-39, NMR, 10 structures | solution nmr | A | — | — |
| 1ET1 | Crystal structure of human parathyroid hormone 1-34 at 0.9 a resolution | x-ray diffraction | A, B | — | — |
| 1ET1 | Crystal structure of human parathyroid hormone 1-34 at 0.9 a resolution | x-ray diffraction | A, B | — | — |
| 1FVY | Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone | solution nmr | A | — | — |
| 1FVY | Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone | solution nmr | A | — | — |
| 1HPH | Structure of human parathyroid hormone 1-37 in solution | solution nmr | A | — | — |
| 1HPH | Structure of human parathyroid hormone 1-37 in solution | solution nmr | A | — | — |
| 1HPY | The solution structure of human parathyroid hormone fragment 1-34 in 20% trifluorethanol, NMR, 10… | solution nmr | A | — | — |
| 1HPY | The solution structure of human parathyroid hormone fragment 1-34 in 20% trifluorethanol, NMR, 10… | solution nmr | A | — | — |
| 1HTH | The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures | solution nmr | A | — | — |
| 1HTH | The solution structure of cyclic human parathyroid hormone fragment 1- 34, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWA | Structure of human parathyroid hormone fragment 1-34, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWA | Structure of human parathyroid hormone fragment 1-34, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWB | Structure of human parathyroid hormone fragment 2-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWB | Structure of human parathyroid hormone fragment 2-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWD | Structure of human parathyroid hormone fragment 3-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWD | Structure of human parathyroid hormone fragment 3-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWE | Structure of human parathyroid hormone fragment 4-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWE | Structure of human parathyroid hormone fragment 4-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWF | Structure of N-terminal acetylated human parathyroid hormone, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWF | Structure of N-terminal acetylated human parathyroid hormone, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWG | Succinyl human parathyroid hormone 4-37, NMR, 10 structures | solution nmr | A | — | — |
| 1ZWG | Succinyl human parathyroid hormone 4-37, NMR, 10 structures | solution nmr | A | — | — |
| 2L1X | The Solution Structure Of Human Parathyroid Hormone-Related Protein | solution nmr | A | — | — |
| 2L1X | The solution structure of human parathyroid hormone-related protein | solution nmr | A | — | — |
| 3C4M | Structure of human parathyroid hormone in complex with the extracellular domain of its… | x-ray diffraction | C, D | — | — |
| 3C4M | Structure of human parathyroid hormone in complex with the extracellular domain of its… | x-ray diffraction | C, D | — | — |
| 7VVK | Pth-bound human PTH1R in complex with gs (CLASS1) | electron microscopy | P | — | — |
| 7VVL | PTH-bound human PTH1R in complex with Gs (class2) | electron microscopy | P | — | 4 (best 0.64) |
| 7VVL | Pth-bound human PTH1R in complex with gs (CLASS2) | electron microscopy | P | — | — |
| 7VVM | Pth-bound human PTH1R in complex with gs (CLASS3) | electron microscopy | P | — | — |
| 7VVN | PTH-bound human PTH1R in complex with Gs (class4) | electron microscopy | P | — | — |
| 7VVN | Pth-bound human PTH1R in complex with gs (CLASS4) | electron microscopy | P | — | — |
| 7VVO | Pth-bound human PTH1R in complex with gs (CLASS5) | electron microscopy | P | — | — |
| 8HA0 | Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 | electron microscopy | P | — | 2 (best 0.52) |
| 8T5F | De novo design of high-affinity protein binders to bioactive helical peptides | x-ray diffraction | C, B, A | — | — |
| P01270 | AlphaFold monomer V2.0 prediction for parathyroid hormone (P01270) | predicted | A | — | — |
Experiment against prediction
- 7VVL chain P against the predicted model P01270: TM-score 0.91, RMSD 0.80 Å
- 7VVL chain P against the predicted model P01270: TM-score 0.91, RMSD 0.80 Å
- 8T5F chain C against the predicted model P01270: TM-score 0.89, RMSD 0.61 Å
- 8HA0 chain P against the predicted model P01270: TM-score 0.88, RMSD 0.90 Å
- 7VVO chain P against the predicted model P01270: TM-score 0.85, RMSD 0.22 Å
- 1ET1 chain A against the predicted model P01270: TM-score 0.82, RMSD 1.32 Å
- 1ET1 chain A against the predicted model P01270: TM-score 0.82, RMSD 1.32 Å
- 7VVM chain P against the predicted model P01270: TM-score 0.81, RMSD 0.89 Å
- 7VVK chain P against the predicted model P01270: TM-score 0.79, RMSD 0.91 Å
- 8T5F chain A against the predicted model P01270: TM-score 0.75, RMSD 1.18 Å
Elsewhere
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