UniProt P01133
Epidermal growth factor (P01133)
Epidermal growth factor (UniProt P01133): 19 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01133
- Protein
- Epidermal growth factor
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 32 · 6 records with a druggable one
Structures
20 records of P01133 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IVO | Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular… | x-ray diffraction | C, D | — | — |
| 1IVO | Crystal structure of the complex of human epidermal growth factor and receptor extracellular… | x-ray diffraction | C, D | — | — |
| 1JL9 | Crystal Structure of Human Epidermal Growth Factor | x-ray diffraction | A, B | — | — |
| 1JL9 | Crystal structure of human epidermal growth factor | x-ray diffraction | A, B | — | — |
| 1NQL | Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an… | x-ray diffraction | B | — | — |
| 1NQL | Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an… | x-ray diffraction | B | — | — |
| 1P9J | Solution structure and dynamics of the EGF/TGF-alpha chimera T1E | solution nmr | A | — | — |
| 1P9J | Solution structure and dynamics of the EGF/TGF-alpha chimera T1E | solution nmr | A | — | — |
| 7OM4 | Nanobody EgB4 bound to the full extracellular EGFR-EGF complex | x-ray diffraction | C | NAG | 4 (best 0.70) |
| 7OM4 | Nanobody EGB4 bound to the full extracellular EGFR-EGF complex | x-ray diffraction | C | — | — |
| 7SYD | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF… | electron microscopy | C, D | — | 7 (best 0.73) |
| 7SYD | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF… | electron microscopy | C, D | — | — |
| 7SYE | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF.… | electron microscopy | C, D | — | 5 (best 0.75) |
| 7SYE | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF.… | electron microscopy | C, D | — | — |
| 7SZ0 | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF.… | electron microscopy | C, D | — | 5 (best 0.79) |
| 7SZ0 | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF.… | electron microscopy | C, D | — | — |
| 7SZ1 | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF.… | electron microscopy | C, D | — | — |
| 8HGO | The EGF-bound EGFR/HER2 ectodomain complex | electron microscopy | C | — | 3 (best 0.79) |
| 8HGS | The EGF-bound EGFR ectodomain homodimer | electron microscopy | C, D | — | 8 (best 0.77) |
| P01133 | AlphaFold monomer V2.0 prediction for pro-epidermal growth factor (P01133) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 7SYD chain C against the predicted model P01133: TM-score 0.80, RMSD 1.29 Å
- 7SYD chain C against the predicted model P01133: TM-score 0.80, RMSD 1.29 Å
- 7SYD chain D against the predicted model P01133: TM-score 0.80, RMSD 1.29 Å
- 7SYD chain D against the predicted model P01133: TM-score 0.80, RMSD 1.29 Å
- 1IVO chain D against the predicted model P01133: TM-score 0.80, RMSD 1.22 Å
- 1IVO chain D against the predicted model P01133: TM-score 0.80, RMSD 1.22 Å
- 1IVO chain C against the predicted model P01133: TM-score 0.79, RMSD 1.65 Å
- 1IVO chain C against the predicted model P01133: TM-score 0.79, RMSD 1.65 Å
- 8HGO chain C against the predicted model P01133: TM-score 0.79, RMSD 1.29 Å
- 7SZ0 chain D against the predicted model P01133: TM-score 0.79, RMSD 1.70 Å
Elsewhere
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