UniProt P01033
Metalloproteinase inhibitor 1 (P01033)
Metalloproteinase inhibitor 1 (UniProt P01033): 20 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01033
- Protein
- Metalloproteinase inhibitor 1
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 15 · 4 records with a druggable one
Structures
21 records of P01033 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D2B | The mmp-inhibitory, N-terminal domain of human tissue inhibitor of metalloproteinases-1 (N-timp-1)… | solution nmr | A | — | — |
| 1D2B | The mmp-inhibitory, N-terminal domain of human tissue inhibitor of metalloproteinases-1 (N-timp-1)… | solution nmr | A | — | — |
| 1OO9 | Orientation in Solution of MMP-3 Catalytic Domain and N-TIMP-1 from Residual Dipolar Couplings | solution nmr | B | — | — |
| 1OO9 | Orientation in solution of mmp-3 catalytic domain and N-timp-1 from residual dipolar couplings | solution nmr | B | — | — |
| 1UEA | Mmp-3/TIMP-1 complex | x-ray diffraction | B, D | — | — |
| 1UEA | Mmp-3/TIMP-1 complex | x-ray diffraction | B, D | — | — |
| 2J0T | Crystal Structure of the Catalytic Domain of MMP-1 in Complex with the Inhibitory Domain of TIMP-1 | x-ray diffraction | D, E, F | — | — |
| 2J0T | Crystal structure of the catalytic domain of mmp-1 in complex with the inhibitory domain of timp-1 | x-ray diffraction | D, E, F | — | — |
| 3MA2 | Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of… | x-ray diffraction | B, C | — | — |
| 3MA2 | Complex membrane type-1 matrix metalloproteinase (MT1-mmp) with tissue inhibitor of… | x-ray diffraction | B, C | — | — |
| 3V96 | Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of… | x-ray diffraction | A | — | — |
| 3V96 | Complex of matrix metalloproteinase-10 catalytic domain (mmp-10CD) with tissue inhibitor of… | x-ray diffraction | A | — | — |
| 6MAV | Complex of tissue inhibitor of metalloproteinase-1 (TIMP-1) mutant L34G with matrix… | x-ray diffraction | B | ZN | 4 (best 0.70) |
| 6MAV | Complex of tissue inhibitor of metalloproteinase-1 (timp-1) mutant L34G with matrix… | x-ray diffraction | B | ZN | — |
| 6N9D | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/L133P/L151C/G154A) with… | x-ray diffraction | B | ZN | — |
| 6N9D | Complex of tissue inhibitor of metalloproteinases-1 (timp-1) mutant (L34G/L133P/L151C/G154A) with… | x-ray diffraction | B | ZN | — |
| 7S7L | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L)… | x-ray diffraction | B | ZN, SO4 | 4 (best 0.69) |
| 7S7L | Complex of tissue inhibitor of metalloproteinases-1 (timp-1) mutant (L34G/M66S/E67Y/L133N/S155L)… | x-ray diffraction | B | ZN, SO4 | — |
| 7S7M | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N)… | x-ray diffraction | B | ZN | 6 (best 0.64) |
| 7S7M | Complex of tissue inhibitor of metalloproteinases-1 (timp-1) mutant (L34G/M66D/T98G/P131S/Q153N)… | x-ray diffraction | B | ZN | — |
| P01033 | AlphaFold monomer V2.0 prediction for metalloproteinase inhibitor 1 (P01033) | predicted | A | — | 1 (best 0.50) |
Ligands
Experiment against prediction
- 3MA2 chain B against the predicted model P01033: TM-score 0.97, RMSD 0.73 Å
- 3MA2 chain B against the predicted model P01033: TM-score 0.97, RMSD 0.73 Å
- 7S7M chain B against the predicted model P01033: TM-score 0.97, RMSD 0.86 Å
- 7S7M chain B against the predicted model P01033: TM-score 0.97, RMSD 0.86 Å
- 7S7L chain B against the predicted model P01033: TM-score 0.97, RMSD 0.91 Å
- 7S7L chain B against the predicted model P01033: TM-score 0.97, RMSD 0.91 Å
- 3MA2 chain C against the predicted model P01033: TM-score 0.97, RMSD 0.96 Å
- 3MA2 chain C against the predicted model P01033: TM-score 0.97, RMSD 0.96 Å
- 6N9D chain B against the predicted model P01033: TM-score 0.96, RMSD 0.97 Å
- 6N9D chain B against the predicted model P01033: TM-score 0.96, RMSD 0.97 Å
Elsewhere
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