UniProt P01023
Alpha-2-macroglobulin (P01023)
Alpha-2-macroglobulin (UniProt P01023): 22 experimental structures and 3 predicted models on GenesisL1, 3 ligands bound, 172 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01023
- Protein
- Alpha-2-macroglobulin
- Experimental structures
- 22
- Predicted models
- 3
- Ligands
- 3
- Pockets
- 172 · 9 records with a druggable one
Structures
25 records of P01023 in the MolNFT archive: 22 experimental, 3 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AYO | Receptor binding domain of bovine alpha-2-macroglobulin | x-ray diffraction | A, B | — | — |
| 1AYO | Receptor binding domain of bovine alpha-2-macroglobulin | x-ray diffraction | A, B | — | — |
| 1BV8 | Receptor domain from alpha-2-macroglobulin | solution nmr | A | — | — |
| 1BV8 | Receptor domain from alpha-2-macroglobulin | solution nmr | A | — | — |
| 6TAV | Crystal structure of endopeptidase-induced alpha2-macroglobulin | x-ray diffraction | A, B, C, D | NAG, BMA, MAN | 20 (best 0.78) |
| 6TAV | Crystal structure of endopeptidase-induced ALPHA2-macroglobulin | x-ray diffraction | A, B, C, D | NAG, BMA, MAN | — |
| 7O7L | (h-alpha2M)4 native I | electron microscopy | A, B, C, D | NAG | 20 (best 0.89) |
| 7O7L | (H-ALPHA2M)4 native I | electron microscopy | A, B, C, D | NAG | — |
| 7O7M | (h-alpha2M)4 native II | electron microscopy | A, B, C, D | NAG | 20 (best 0.88) |
| 7O7M | (H-ALPHA2M)4 native II | electron microscopy | A, B, C, D | NAG | — |
| 7O7N | (H-ALPHA2M)4 semiactivated I state | electron microscopy | A, B, C, D | NAG | — |
| 7O7O | (h-alpha2M)4 semiactivated II state | electron microscopy | A, B, C, D | NAG | 20 (best 0.88) |
| 7O7O | (H-ALPHA2M)4 semiactivated II state | electron microscopy | A, B, C, D | NAG | — |
| 7O7P | (h-alpha2M)4 activated state | electron microscopy | A, B, C, D | NAG | 20 (best 0.79) |
| 7O7P | (H-ALPHA2M)4 activated state | electron microscopy | A, B, C, D | NAG | — |
| 7O7Q | (h-alpha2M)4 trypsin-activated state | electron microscopy | A, B, C, D | NAG | 20 (best 0.77) |
| 7O7Q | (H-ALPHA2M)4 trypsin-activated state | electron microscopy | A, B, C, D | NAG | — |
| 7O7R | (h-alpha2M)4 plasmin-activated I state | electron microscopy | A, B, C, D | NAG | 20 (best 0.79) |
| 7O7R | (H-ALPHA2M)4 plasmin-activated I state | electron microscopy | A, B, C, D | NAG | — |
| 7O7S | (H-ALPHA2M)4 plasmin-activated II state | electron microscopy | A, B, C, D | NAG, BMA | — |
| 7VON | Native alpha-2-macroglobulin monomer | electron microscopy | A | — | 20 (best 0.80) |
| 7VOO | Induced alpha-2-macroglobulin monomer | electron microscopy | A | NAG | 12 (best 0.81) |
| 2P9R | Human alpha2-macroglogulin is composed of multiple domains, as predicted by homology with… | x-ray diffraction | A, B | — | — |
| 2P9R | Human ALPHA2-macroglogulin is composed of multiple domains, as predicted by homology with… | x-ray diffraction | A, B | — | — |
| P01023 | AlphaFold monomer V2.0 prediction for alpha-2-macroglobulin (P01023) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1AYO chain B against the predicted model P01023: TM-score 0.98, RMSD 0.68 Å
- 1AYO chain B against the predicted model P01023: TM-score 0.98, RMSD 0.68 Å
- 1AYO chain A against the predicted model P01023: TM-score 0.97, RMSD 0.73 Å
- 1AYO chain A against the predicted model P01023: TM-score 0.97, RMSD 0.73 Å
- 6TAV chain B against the predicted model 2P9R: TM-score 0.08, RMSD 0.85 Å
- 6TAV chain B against the predicted model 2P9R: TM-score 0.08, RMSD 0.85 Å
- 6TAV chain B against the predicted model 2P9R: TM-score 0.08, RMSD 0.85 Å
- 6TAV chain B against the predicted model 2P9R: TM-score 0.08, RMSD 0.85 Å
- 6TAV chain C against the predicted model 2P9R: TM-score 0.08, RMSD 0.86 Å
- 6TAV chain C against the predicted model 2P9R: TM-score 0.08, RMSD 0.86 Å
Elsewhere
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