UniProt P00808
Beta-lactamase (P00808)
Beta-lactamase (UniProt P00808), EC 3.5.2.6: 50 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00808
- Protein
- Beta-lactamase
- EC
- 3.5.2.6
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 17 · 4 records with a druggable one
Structures
51 records of P00808 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1I2S | Beta-lactamase from bacillus licheniformis BS3 | x-ray diffraction | A, B | — | — |
| 1I2S | Beta-lactamase from bacillus licheniformis BS3 | x-ray diffraction | A, B | — | — |
| 1I2W | Beta-lactamase from bacillus licheniformis BS3 complexed with cefoxitin | x-ray diffraction | A, B | — | — |
| 1I2W | Beta-lactamase from bacillus licheniformis BS3 complexed with cefoxitin | x-ray diffraction | A, B | — | — |
| 1MBL | A catalytically-impaired class A beta-lactamase: 2 Angstroms crystal structure and kinetics of the… | x-ray diffraction | A, B | — | — |
| 1MBL | A catalytically-impaired class a beta-lactamase: 2 ångströms crystal structure and kinetics of the… | x-ray diffraction | A, B | — | — |
| 2BLM | Beta-lactamase of bacillus licheniformis 749(SLASH)C at 2 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2BLM | Beta-lactamase of bacillus licheniformis 749(SLASH)C at 2 ångströms resolution | x-ray diffraction | A, B | — | — |
| 3LY3 | Crystal Structure of fluorophore-labeled Class A Beta-lactamase PenP | x-ray diffraction | A | — | — |
| 3LY3 | Crystal structure of fluorophore-labeled class a beta-lactamase penp | x-ray diffraction | A | — | — |
| 3LY4 | Crystal Structure of fluorophore-labeled Class A -lactamase PenP-E166Cb in complex with penicillin G | x-ray diffraction | A | — | — |
| 3LY4 | Crystal structure of fluorophore-labeled class a -lactamase penp- E166CB in complex with penicillin… | x-ray diffraction | A | — | — |
| 3M2J | Crystal Structure of fluorescein-labeled Class A -lactamase PenP | x-ray diffraction | A, B | — | — |
| 3M2J | Crystal structure of fluorescein-labeled class a -lactamase penp | x-ray diffraction | A, B | — | — |
| 3M2K | Crystal Structure of fluorescein-labeled Class A -beta lactamase PenP in complex with cefotaxime | x-ray diffraction | A, B | — | — |
| 3M2K | Crystal structure of fluorescein-labeled class a -beta lactamase penp in complex with cefotaxime | x-ray diffraction | A, B | — | — |
| 3SH7 | Crystal structure of fluorophore-labeled beta-lactamase PenP | x-ray diffraction | A, B | — | — |
| 3SH7 | Crystal structure of fluorophore-labeled beta-lactamase penp | x-ray diffraction | A, B | — | — |
| 3SH8 | Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cephaloridine | x-ray diffraction | A, B | — | — |
| 3SH8 | Crystal structure of fluorophore-labeled beta-lactamase penp in complex with cephaloridine | x-ray diffraction | A, B | — | — |
| 3SH9 | Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cefotaxime | x-ray diffraction | A, B | — | — |
| 3SH9 | Crystal structure of fluorophore-labeled beta-lactamase penp in complex with cefotaxime | x-ray diffraction | A, B | — | — |
| 3SOI | Crystallographic structure of Bacillus licheniformis beta-lactamase W210F/W229F/W251F at 1.73… | x-ray diffraction | A, B | — | — |
| 3SOI | Crystallographic structure of bacillus licheniformis beta-lactamase W210F/W229F/W251F at 1.73… | x-ray diffraction | A, B | — | — |
| 4BLM | Beta-lactamase of bacillus licheniformis 749(SLASH)C. refinement at 2 ångströms resolution and… | x-ray diffraction | A, B | — | — |
| 4BLM | Beta-lactamase of bacillus licheniformis 749(SLASH)C. refinement at 2 ångströms resolution and… | x-ray diffraction | A, B | — | — |
| 4M3K | Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP… | x-ray diffraction | A | — | — |
| 4M3K | Structure of a single domain camelid antibody fragment cab-H7S in complex with the blap… | x-ray diffraction | A | — | — |
| 4N1H | Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP… | x-ray diffraction | A, C | — | — |
| 4N1H | Structure of a single-domain camelid antibody fragment cab-F11N in complex with the blap… | x-ray diffraction | A, C | — | — |
| 4N92 | Crystal structure of beta-lactamse PenP_E166S | x-ray diffraction | B, A | — | — |
| 4N92 | Crystal structure of beta-lactamse PENP_E166S | x-ray diffraction | B, A | — | — |
| 4N9K | crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine | x-ray diffraction | B, A | — | — |
| 4N9K | Crystal structure of beta-lactamse PENP_E166S in complex with cephaloridine | x-ray diffraction | B, A | — | — |
| 4N9L | crystal structure of beta-lactamse PenP_E166S in complex with meropenem | x-ray diffraction | B, A | — | — |
| 4N9L | Crystal structure of beta-lactamse PENP_E166S in complex with meropenem | x-ray diffraction | B, A | — | — |
| 5GHX | Crystal structure of beta-lactamase PenP mutant-E166H | x-ray diffraction | A, B | — | — |
| 5GHX | Crystal structure of beta-lactamase penp mutant-E166H | x-ray diffraction | A, B | — | — |
| 5GHY | Crystal structure of beta-lactamase PenP mutant-E166H in complex with cephaloridine as… | x-ray diffraction | B, A | CED | — |
| 5GHY | Crystal structure of beta-lactamase penp mutant-E166H in complex with cephaloridine as… | x-ray diffraction | B, A | — | — |
| 5GHZ | Crystal structure of beta-lactamase PenP mutant-E166H in complex with cephaloridine as… | x-ray diffraction | B, A | CED | 4 (best 0.74) |
| 5GHZ | Crystal structure of beta-lactamase penp mutant-E166H in complex with cephaloridine as… | x-ray diffraction | B, A | — | — |
| 5LWF | Structure of a single domain camelid antibody fragment cAb-G10S in complex with the BlaP… | x-ray diffraction | A, B | — | 5 (best 0.75) |
| 5LWF | Structure of a single domain camelid antibody fragment cab-G10S in complex with the blap… | x-ray diffraction | A, B | — | — |
| 5ZFL | Crystal structure of beta-lactamase PenP mutant E166Y | x-ray diffraction | A, B | — | 4 (best 0.73) |
| 5ZFL | Crystal structure of beta-lactamase penp mutant E166Y | x-ray diffraction | A, B | — | — |
| 5ZFT | Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as… | x-ray diffraction | A, B | CED | — |
| 5ZFT | Crystal structure of beta-lactamase penp mutant-E166Y in complex with cephaloridine as… | x-ray diffraction | A, B | CED | — |
| 5ZG6 | Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as… | x-ray diffraction | B, A | CED | 4 (best 0.73) |
| 5ZG6 | Crystal structure of beta-lactamase penp mutant-E166Y in complex with cephaloridine as… | x-ray diffraction | B, A | CED | — |
| P00808 | AlphaFold monomer V2.0 prediction for beta-lactamase (P00808) | predicted | A | — | — |
Ligands
- CED · 5-methyl-2-[2-oxo-1-(2-thiophen-2-yl-acetylamino)-ethyl]-3,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid · in 6 records
Experiment against prediction
- 1I2S chain A against the predicted model P00808: TM-score 1.00, RMSD 0.35 Å
- 1I2S chain A against the predicted model P00808: TM-score 1.00, RMSD 0.35 Å
- 5ZG6 chain A against the predicted model P00808: TM-score 1.00, RMSD 0.36 Å
- 5ZG6 chain A against the predicted model P00808: TM-score 1.00, RMSD 0.36 Å
- 5ZFT chain B against the predicted model P00808: TM-score 1.00, RMSD 0.36 Å
- 5ZFT chain B against the predicted model P00808: TM-score 1.00, RMSD 0.36 Å
- 5ZFL chain B against the predicted model P00808: TM-score 1.00, RMSD 0.37 Å
- 5ZFL chain B against the predicted model P00808: TM-score 1.00, RMSD 0.37 Å
- 5GHZ chain A against the predicted model P00808: TM-score 1.00, RMSD 0.37 Å
- 5GHZ chain A against the predicted model P00808: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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