UniProt P00568
Adenylate kinase isoenzyme 1 (P00568)
Adenylate kinase isoenzyme 1 (UniProt P00568), EC 2.7.4.3, 2.7.4.6: 8 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00568
- Protein
- Adenylate kinase isoenzyme 1
- EC
- 2.7.4.3, 2.7.4.6
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
9 records of P00568 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z83 | Crystal structure of human AK1A in complex with AP5A | x-ray diffraction | A, B, C | — | — |
| 1Z83 | Crystal structure of human AK1A in complex with AP5A | x-ray diffraction | A, B, C | — | — |
| 2C95 | Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate | x-ray diffraction | A, B | — | — |
| 2C95 | Structure of adenylate kinase 1 in complex with P1,P4-DI(ADENOSINE) tetraphosphate | x-ray diffraction | A, B | — | — |
| 7DE3 | Human adenylate kinase 1 (hAK1) mutant-R128W | x-ray diffraction | A | — | — |
| 7DE3 | Human adenylate kinase 1 (HAK1) mutant-R128W | x-ray diffraction | A | — | — |
| 7X7S | Solution structure of human adenylate kinase 1 (hAK1) | solution nmr | A | — | 1 (best 0.65) |
| 7X7S | Solution structure of human adenylate kinase 1 (HAK1) | solution nmr | A | — | — |
| P00568 | AlphaFold monomer V2.0 prediction for adenylate kinase isoenzyme 1 (P00568) | predicted | A | — | — |
Experiment against prediction
- 1Z83 chain A against the predicted model P00568: TM-score 0.98, RMSD 0.65 Å
- 1Z83 chain A against the predicted model P00568: TM-score 0.98, RMSD 0.65 Å
- 2C95 chain A against the predicted model P00568: TM-score 0.97, RMSD 0.82 Å
- 2C95 chain A against the predicted model P00568: TM-score 0.97, RMSD 0.82 Å
- 2C95 chain B against the predicted model P00568: TM-score 0.97, RMSD 0.95 Å
- 2C95 chain B against the predicted model P00568: TM-score 0.97, RMSD 0.95 Å
- 7DE3 chain A against the predicted model P00568: TM-score 0.79, RMSD 3.15 Å
- 7DE3 chain A against the predicted model P00568: TM-score 0.79, RMSD 3.15 Å
- 7X7S chain A against the predicted model P00568: TM-score 0.75, RMSD 3.48 Å
- 7X7S chain A against the predicted model P00568: TM-score 0.75, RMSD 3.48 Å
Elsewhere
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