UniProt P00517
cAMP-dependent protein kinase catalytic subunit alpha (P00517)
cAMP-dependent protein kinase catalytic subunit alpha (UniProt P00517), EC 2.7.11.11: 187 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 51 pockets. Binding sites, druggability and experiment…
- UniProt
- P00517
- Protein
- cAMP-dependent protein kinase catalytic subunit alpha
- EC
- 2.7.11.11
- Experimental structures
- 187
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 51 · 12 records with a druggable one
Structures
188 records of P00517 in the MolNFT archive: 187 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CDK | Camp-dependent protein kinase catalytic subunit (E.C.2.7.1.37) (protein kinase a) complexed with… | x-ray diffraction | A, B | — | — |
| 1CDK | Camp-dependent protein kinase catalytic subunit (E.C.2.7.1.37) (protein kinase a) complexed with… | x-ray diffraction | A, B | — | — |
| 1CMK | Crystal structures of the myristylated catalytic subunit of camp-dependent protein kinase reveal… | x-ray diffraction | E | — | — |
| 1CMK | Crystal structures of the myristylated catalytic subunit of camp- dependent protein kinase reveal… | x-ray diffraction | E | — | — |
| 1Q24 | PKA double mutant model of PKB in complex with MgATP | x-ray diffraction | A | — | — |
| 1Q24 | PKA double mutant model of pkb in complex with mgatp | x-ray diffraction | A | — | — |
| 1Q61 | PKA triple mutant model of PKB | x-ray diffraction | A | — | — |
| 1Q61 | PKA triple mutant model of pkb | x-ray diffraction | A | — | — |
| 1Q62 | PKA double mutant model of PKB | x-ray diffraction | A | — | — |
| 1Q62 | PKA double mutant model of pkb | x-ray diffraction | A | — | — |
| 1Q8T | The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor… | x-ray diffraction | A | — | — |
| 1Q8T | The catalytic subunit of camp-dependent protein kinase (PKA) in complex with rho-kinase inhibitor… | x-ray diffraction | A | — | — |
| 1Q8U | The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P | x-ray diffraction | A | — | — |
| 1Q8U | The catalytic subunit of camp-dependent protein kinase in complex with rho-kinase inhibitor H-1152P | x-ray diffraction | A | — | — |
| 1Q8W | The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil… | x-ray diffraction | A | — | — |
| 1Q8W | The catalytic subunit of camp-dependent protein kinase in complex with rho-kinase inhibitor fasudil… | x-ray diffraction | A | — | — |
| 1SMH | Protein kinase A variant complex with completely ordered N-terminal helix | x-ray diffraction | A | — | — |
| 1SMH | Protein kinase a variant complex with completely ordered N-terminal helix | x-ray diffraction | A | — | — |
| 1STC | Camp-dependent protein kinase, alpha-catalytic subunit in complex with staurosporine | x-ray diffraction | E | — | — |
| 1STC | Camp-dependent protein kinase, alpha-catalytic subunit in complex with staurosporine | x-ray diffraction | E | — | — |
| 1SVE | Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1 | x-ray diffraction | A | — | — |
| 1SVE | Crystal structure of protein kinase a in complex with azepane derivative 1 | x-ray diffraction | A | — | — |
| 1SVG | Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4 | x-ray diffraction | A | — | — |
| 1SVG | Crystal structure of protein kinase a in complex with azepane derivative 4 | x-ray diffraction | A | — | — |
| 1SVH | Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8 | x-ray diffraction | A | — | — |
| 1SVH | Crystal structure of protein kinase a in complex with azepane derivative 8 | x-ray diffraction | A | — | — |
| 1SZM | Dual binding mode of bisindolylmaleimide 2 to protein kinase a (PKA) | x-ray diffraction | A, B | — | — |
| 1SZM | Dual binding mode of bisindolylmaleimide 2 to protein kinase a (PKA) | x-ray diffraction | A, B | — | — |
| 1VEB | Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5 | x-ray diffraction | A | — | — |
| 1VEB | Crystal structure of protein kinase a in complex with azepane derivative 5 | x-ray diffraction | A | — | — |
| 1XH4 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XH4 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1XH5 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XH5 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1XH6 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XH6 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1XH7 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XH7 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1XH8 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XH8 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1XH9 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XH9 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1XHA | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | A | — | — |
| 1XHA | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | A | — | — |
| 1YDR | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H7 protein… | x-ray diffraction | E | — | — |
| 1YDR | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H7 protein… | x-ray diffraction | E | — | — |
| 1YDS | Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein… | x-ray diffraction | E | — | — |
| 1YDS | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein… | x-ray diffraction | E | — | — |
| 1YDT | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H89 protein… | x-ray diffraction | E | — | — |
| 1YDT | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H89 protein… | x-ray diffraction | E | — | — |
| 2C1A | Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid… | x-ray diffraction | A | — | — |
| 2C1A | Structure of camp-dependent protein kinase complexed with isoquinoline-5-sulfonic acid… | x-ray diffraction | A | — | — |
| 2C1B | Structure of cAMP-dependent protein kinase complexed with… | x-ray diffraction | A | — | — |
| 2C1B | Structure of camp-dependent protein kinase complexed with (4R,2S)-5'… | x-ray diffraction | A | — | — |
| 2F7E | PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine | x-ray diffraction | E | — | — |
| 2F7E | PKA complexed with (S)-2-(1H-indol-3-yl)-1-(5-isoquinolin-6- yl-pyridin-3-yloxymethyl-etylamine | x-ray diffraction | E | — | — |
| 2F7X | Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethy… | x-ray diffraction | E | — | — |
| 2F7X | Protein kinase a bound to (S)-2-(1H-indol-3-yl)-1-[5-((E)-2… | x-ray diffraction | E | — | — |
| 2F7Z | Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-eh… | x-ray diffraction | E | — | — |
| 2F7Z | Protein kinase a bound to (R)-1-(1H-indol-3-ylmethyl)-2-(2… | x-ray diffraction | E | — | — |
128 records more on the page itself.
Ligands
- MG · Magnesium ion · in 4 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
- 9CY · N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-4-(pyridin-4-yl)benzamide · in 2 records
- 9D1 · 3-({[6-(pyridin-4-yl)-1,3-benzothiazol-2-yl][2-(pyrrolidin-1-yl)ethyl]amino}methyl)phenol · in 2 records
- 9D4 · N-[(3-fluorophenyl)methyl]-6-(pyridin-4-yl)-1,3-benzothiazol-2-amine · in 2 records
- J0G · 2-[(2-aminoethyl)amino]-N-[(1R)-1-(3-methoxyphenyl) ethyl]-4-(pyridin-4-yl)benzamide · in 2 records
- J0P · N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide · in 2 records
- 4L7 · 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- ZWG · N-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-D-leucinamide · in 1 record
Experiment against prediction
- 5VHB chain A against the predicted model P00517: TM-score 1.00, RMSD 0.33 Å
- 2OJF chain E against the predicted model P00517: TM-score 1.00, RMSD 0.37 Å
- 3DND chain A against the predicted model P00517: TM-score 1.00, RMSD 0.39 Å
- 4IE9 chain A against the predicted model P00517: TM-score 1.00, RMSD 0.40 Å
- 2C1A chain A against the predicted model P00517: TM-score 1.00, RMSD 0.40 Å
- 2JDT chain A against the predicted model P00517: TM-score 1.00, RMSD 0.40 Å
- 1YDR chain E against the predicted model P00517: TM-score 1.00, RMSD 0.41 Å
- 1YDS chain E against the predicted model P00517: TM-score 1.00, RMSD 0.41 Å
- 1XH5 chain A against the predicted model P00517: TM-score 1.00, RMSD 0.42 Å
- 4YXS chain A against the predicted model P00517: TM-score 1.00, RMSD 0.42 Å
Elsewhere
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