UniProt P00366
Glutamate dehydrogenase 1, mitochondrial (P00366)
Glutamate dehydrogenase 1, mitochondrial (UniProt P00366), EC 1.4.1.3: 23 experimental structures and 1 predicted model on GenesisL1, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00366
- Protein
- Glutamate dehydrogenase 1, mitochondrial
- EC
- 1.4.1.3
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 40 · 2 records with a druggable one
Structures
24 records of P00366 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HWY | Bovine glutamate dehydrogenase complexed with NAD and 2-oxoglutarate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1HWY | Bovine glutamate dehydrogenase complexed with NAD and 2-oxoglutarate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1NQT | Crystal structure of bovine Glutamate dehydrogenase-ADP complex | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1NQT | Crystal structure of bovine glutamate dehydrogenase-ADP complex | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1NR7 | Crystal structure of apo bovine glutamate dehydrogenase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1NR7 | Crystal structure of apo bovine glutamate dehydrogenase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3JCZ | Structure of bovine glutamate dehydrogenase in the unliganded state | electron microscopy | A, B, C, D, E, F | — | — |
| 3JCZ | Structure of bovine glutamate dehydrogenase in the unliganded state | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD0 | Glutamate dehydrogenase in complex with GTP | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD0 | Glutamate dehydrogenase in complex with GTP | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD1 | Glutamate dehydrogenase in complex with NADH, closed conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD1 | Glutamate dehydrogenase in complex with NADH, closed conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD2 | Glutamate dehydrogenase in complex with NADH, open conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD2 | Glutamate dehydrogenase in complex with NADH, open conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD3 | Glutamate dehydrogenase in complex with NADH and GTP, open conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD3 | Glutamate dehydrogenase in complex with NADH and GTP, open conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD4 | Glutamate dehydrogenase in complex with NADH and GTP, closed conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 3JD4 | Glutamate dehydrogenase in complex with NADH and GTP, closed conformation | electron microscopy | A, B, C, D, E, F | — | — |
| 5K12 | Cryo-EM structure of glutamate dehydrogenase at 1.8 A resolution | electron microscopy | A, B, C, D, E, F | — | — |
| 5K12 | Cryo-EM structure of glutamate dehydrogenase at 1.8 a resolution | electron microscopy | A, B, C, D, E, F | — | — |
| 7VDA | 2.26 A structure of the glutamate dehydrogenase | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.88) |
| 7VDA | 2.26 a structure of the glutamate dehydrogenase | electron microscopy | A, B, C, D, E, F | — | — |
| 8EW0 | Cryo-EM structure of glutamate dehydrogenase frozen at various temperature | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.87) |
| P00366 | AlphaFold monomer V2.0 prediction for glutamate dehydrogenase 1, mitochondrial (P00366) | predicted | A | — | — |
Experiment against prediction
- 1HWY chain F against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain F against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain E against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain E against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain A against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain B against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain A against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain B against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain D against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
- 1HWY chain D against the predicted model P00366: TM-score 0.99, RMSD 0.77 Å
Elsewhere
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