UniProt P00325
Alcohol dehydrogenase (P00325)
Alcohol dehydrogenase (UniProt P00325), EC 1.1.1.1: 18 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00325
- Protein
- Alcohol dehydrogenase
- EC
- 1.1.1.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 33 · 8 records with a druggable one
Structures
19 records of P00325 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DEH | Crystallization of human BETA1 alcohol dehydrogenase (15 MG/ML) in 50 mm sodium phosphate (pH 7.5)… | x-ray diffraction | A, B | ZN, NAD, PYZ, CL | 5 (best 0.74) |
| 1DEH | Crystallization of human BETA1 alcohol dehydrogenase (15 MG/ML) in 50 mm sodium phosphate (pH 7.5)… | x-ray diffraction | A, B | — | — |
| 1HDX | Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their… | x-ray diffraction | A, B | ZN, NAD, CXL, CL | 3 (best 0.77) |
| 1HDX | Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their… | x-ray diffraction | A, B | — | — |
| 1HDY | Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their… | x-ray diffraction | A, B | ZN, NAD, PYZ, CL | 6 (best 0.74) |
| 1HDY | Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their… | x-ray diffraction | A, B | — | — |
| 1HDZ | Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their… | x-ray diffraction | A, B | ZN, NAD, CL | 5 (best 0.71) |
| 1HDZ | Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their… | x-ray diffraction | A, B | — | — |
| 1HSZ | Human beta-1 alcohol dehydrogenase (ADH1B*1) | x-ray diffraction | A, B | ZN, NAD, PO4 | 4 (best 0.75) |
| 1HSZ | Human beta-1 alcohol dehydrogenase (ADH1B*1) | x-ray diffraction | A, B | — | — |
| 1HTB | Crystallization of human BETA3 alcohol dehydrogenase (10 MG/ML) in 100 mm sodium phosphate (pH… | x-ray diffraction | A, B | ZN, NAD, PYZ, CL | 4 (best 0.75) |
| 1HTB | Crystallization of human BETA3 alcohol dehydrogenase (10 MG/ML) in 100 mm sodium phosphate (pH… | x-ray diffraction | A, B | — | — |
| 1U3U | Crystal Structure of Human Alcohol Dehydrogenase Beta-1-Beta-1 Isoform Complexed with… | x-ray diffraction | A, B | ZN, NAD, BNF, PO4 | 3 (best 0.76) |
| 1U3U | Crystal structure of human alcohol dehydrogenase beta-1-beta-1 isoform complexed with… | x-ray diffraction | A, B | — | — |
| 1U3V | Crystal Structure of Human Alcohol Dehydrogenase Beta-1-Beta-1 Isoform Complexed with… | x-ray diffraction | A, B | ZN, NAD, HPL, PO4 | 3 (best 0.76) |
| 1U3V | Crystal structure of human alcohol dehydrogenase beta-1-beta-1 isoform complexed with… | x-ray diffraction | A, B | — | — |
| 3HUD | The structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site… | x-ray diffraction | A, B | — | — |
| 3HUD | The structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site… | x-ray diffraction | A, B | — | — |
| P00325 | AlphaFold monomer V2.0 prediction for all-trans-retinol dehydrogenase [NAD(+)] ADH1B (P00325) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1HSZ chain B against the predicted model P00325: TM-score 1.00, RMSD 0.41 Å
- 1HSZ chain B against the predicted model P00325: TM-score 1.00, RMSD 0.41 Å
- 1DEH chain A against the predicted model P00325: TM-score 1.00, RMSD 0.42 Å
- 1DEH chain A against the predicted model P00325: TM-score 1.00, RMSD 0.42 Å
- 1HTB chain A against the predicted model P00325: TM-score 1.00, RMSD 0.42 Å
- 1HTB chain A against the predicted model P00325: TM-score 1.00, RMSD 0.42 Å
- 1U3V chain B against the predicted model P00325: TM-score 1.00, RMSD 0.43 Å
- 1U3V chain B against the predicted model P00325: TM-score 1.00, RMSD 0.43 Å
- 1U3V chain A against the predicted model P00325: TM-score 1.00, RMSD 0.43 Å
- 1U3V chain A against the predicted model P00325: TM-score 1.00, RMSD 0.43 Å
Elsewhere
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