UniProt O95989
Diphosphoinositol polyphosphate phosphohydrolase 1 (O95989)
Diphosphoinositol polyphosphate phosphohydrolase 1 (UniProt O95989), EC 3.6.1.-, 3.6.1.52: 24 experimental structures on GenesisL1, 13 ligands bound, 4 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O95989
- Protein
- Diphosphoinositol polyphosphate phosphohydrolase 1
- EC
- 3.6.1.-, 3.6.1.52
- Experimental structures
- 24
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 4 · 1 record with a druggable one
Structures
24 records of O95989 in the MolNFT archive: 24 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FVV | Human Diphosphoinositol polyphosphate phosphohydrolase 1 | x-ray diffraction | A | — | — |
| 2FVV | Human diphosphoinositol polyphosphate phosphohydrolase 1 | x-ray diffraction | A | — | — |
| 2Q9P | Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex | x-ray diffraction | A | — | — |
| 2Q9P | Human diphosphoinositol polyphosphate phosphohydrolase 1, mg-F complex | x-ray diffraction | A | — | — |
| 6PCK | Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7 | x-ray diffraction | A | O81, MG, CL | — |
| 6PCL | Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7 | x-ray diffraction | A | I7P, MG, CL | — |
| 6WO7 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | I7P, MG, CL, F | — |
| 6WO8 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | U6J, MG, CL, SO4, F | 1 (best 0.47) |
| 6WO8 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | U6J, MG, CL, SO4, F | — |
| 6WO9 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | O81, MG, CL, SO4 | — |
| 6WOA | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | UEV, MG, CL, SO4, F | — |
| 6WOB | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | U71, MG, CL, F | 1 (best 0.48) |
| 6WOB | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | U71, MG, CL, F | — |
| 6WOC | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | I7P, MG, CL | — |
| 6WOD | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol… | x-ray diffraction | A | MG, CL, IHP | — |
| 6WOE | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol… | x-ray diffraction | A | MG, CL, IHP | — |
| 6WOF | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol… | x-ray diffraction | A | MG, CL, IHP | — |
| 6WOG | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | 5A3, SO4 | — |
| 6WOH | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | 4WZ, SO4 | — |
| 6WOI | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | O81, MG, CL, F | — |
| 7TN4 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | MG, CL, F, ZM2 | — |
| 8T98 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with… | x-ray diffraction | A | U6J, MG, CL, F | 1 (best 0.57) |
| 8TF9 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with myo-5-IP7… | x-ray diffraction | A | I7P, MG, CL, F | 1 (best 0.47) |
| O95989 | AlphaFold monomer V2.0 prediction for diphosphoinositol polyphosphate phosphohydrolase 1 (O95989) | — | — | — |
Ligands
- CL · Chloride ion · in 17 records
- MG · Magnesium ion · in 17 records
- F · Fluoride ion · in 10 records
- SO4 · Sulfate ion · in 6 records
- I7P · (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 4 records
- IHP · Inositol hexakisphosphate · in 3 records
- O81 · (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 3 records
- U6J · (1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate · in 3 records
- U71 · (1S,2R,3S,4S,5S,6S)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 2 records
- 4WZ · {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy) cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl) methanediyl]}bis(phosphonic acid) · in 1 record
- 5A3 · Methylenebisphosphonate inositol pentakisphosphate · in 1 record
- UEV · (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 1 record
- ZM2 · (1R,2S,3R,4R,5S,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate · in 1 record
Elsewhere
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