UniProt O95785

Protein Wiz (O95785)

Protein Wiz (UniProt O95785): 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: O95785
Protein: Protein Wiz
Experimental structures: 2
Predicted models: 1
Ligands: 3
Pockets: 17 · 2 records with a druggable one

Structures

3 records of O95785 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8TZX	Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1	x-ray diffraction	C, F	U3I, ZN	4 (best 0.75)
9DJT	Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue WIZ-5	x-ray diffraction	C, F	A1A5H, ZN	4 (best 0.64)
O95785	AlphaFold monomer V2.0 prediction for protein wiz (O95785)	predicted	A	—	9 (best 0.48)

Ligands

ZN · Zinc ion · in 2 records
A1A5H · (3S)-3-(5-{[(4R)-6-ethyl-6-azaspiro[2.5]octan-4-yl]oxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione · in 1 record
U3I · (3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione · in 1 record

Experiment against prediction

8TZX chain F against the predicted model O95785: TM-score 0.80, RMSD 0.70 Å
9DJT chain F against the predicted model O95785: TM-score 0.77, RMSD 1.03 Å
8TZX chain C against the predicted model O95785: TM-score 0.76, RMSD 1.15 Å
9DJT chain C against the predicted model O95785: TM-score 0.76, RMSD 1.67 Å

Elsewhere

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