UniProt O95714
E3 ubiquitin-protein ligase HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (UniProt O95714), EC 2.3.2.26: 19 experimental structures on GenesisL1, 1 ligand bound, 51 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O95714
- Protein
- E3 ubiquitin-protein ligase HERC2
- EC
- 2.3.2.26
- Experimental structures
- 19
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 51 · 6 records with a druggable one
Structures
19 records of O95714 in the MolNFT archive: 19 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KEO | Solution NMR structure of human protein HS00059, cytochrome-b5-like domain of the HERC2 E3 ligase.… | solution nmr | A | — | — |
| 2KEO | Solution NMR structure of human protein HS00059, cytochrome-B5-like domain of the HERC2 E3 ligase.… | solution nmr | A | — | — |
| 3KCI | The third RLD domain of HERC2 | x-ray diffraction | A | — | — |
| 3KCI | The third rld domain of HERC2 | x-ray diffraction | A | — | — |
| 4L1M | Structure of the first RCC1-like domain of HERC2 | x-ray diffraction | A, B, C | — | — |
| 4L1M | Structure of the first RCC1-like domain of HERC2 | x-ray diffraction | A, B, C | — | — |
| 6WW3 | Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail | x-ray diffraction | A, B | ZN | 1 (best 0.33) |
| 6WW3 | Crystal structure of HERC2 zz domain in complex with SUMO1 tail | x-ray diffraction | A, B | ZN | — |
| 6WW4 | Crystal structure of HERC2 ZZ domain in complex with histone H3 tail | x-ray diffraction | B, A | ZN | — |
| 6WW4 | Crystal structure of HERC2 zz domain in complex with histone H3 tail | x-ray diffraction | B, A | ZN | — |
| 7Q40 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 | x-ray diffraction | A, C, E | — | 8 (best 0.72) |
| 7Q41 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of… | x-ray diffraction | A, C, E | — | 9 (best 0.72) |
| 7Q42 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of… | x-ray diffraction | A, C, E | — | 9 (best 0.72) |
| 7Q43 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of… | x-ray diffraction | C, A, E | — | 9 (best 0.72) |
| 7Q44 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of… | x-ray diffraction | A, C, E | — | 7 (best 0.72) |
| 7Q45 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of… | x-ray diffraction | A, C, E | — | — |
| 7Q46 | Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of… | x-ray diffraction | A, C, E | — | 8 (best 0.72) |
| 7RGW | Crystal structure of HERC2 DOC domain | x-ray diffraction | A | — | — |
| 7RGW | Crystal structure of HERC2 doc domain | x-ray diffraction | A | — | — |
Ligands
- ZN · Zinc ion · in 4 records
Experiment against prediction
- 6WW3 chain B against the predicted model P63165: TM-score 0.35, RMSD 3.06 Å
- 6WW3 chain B against the predicted model P63165: TM-score 0.35, RMSD 3.06 Å
- 6WW3 chain A against the predicted model P63165: TM-score 0.34, RMSD 3.95 Å
- 6WW3 chain A against the predicted model P63165: TM-score 0.34, RMSD 3.95 Å
- 6WW4 chain A against the predicted model P68431: TM-score 0.25, RMSD 3.38 Å
- 6WW4 chain A against the predicted model P68431: TM-score 0.25, RMSD 3.38 Å
- 6WW4 chain B against the predicted model P68431: TM-score 0.24, RMSD 3.07 Å
- 6WW4 chain B against the predicted model P68431: TM-score 0.24, RMSD 3.07 Å
Elsewhere
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