UniProt O95551
Tyrosyl-DNA phosphodiesterase 2 (O95551)
Tyrosyl-DNA phosphodiesterase 2 (UniProt O95551), EC 3.1.4.-: 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O95551
- Protein
- Tyrosyl-DNA phosphodiesterase 2
- EC
- 3.1.4.-
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 6 · 1 record with a druggable one
Structures
11 records of O95551 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5INO | Human Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex | x-ray diffraction | A, B | SO4 | — |
| 5INO | Human TDP2 reaction product (5'-phosphorylated DNA)-MG2+ complex | x-ray diffraction | A, B | — | — |
| 5J3P | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 | x-ray diffraction | A, B | MG | — |
| 5J3P | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 | x-ray diffraction | A, B | — | — |
| 5J3S | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with… | x-ray diffraction | A | 6FQ | 2 (best 0.49) |
| 5J3S | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with… | x-ray diffraction | A | — | — |
| 6Q00 | TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1 | x-ray diffraction | B | K | — |
| 6Q00 | TDP2 uba domain bound to ubiquitin at 0.85 ångströms resolution, crystal form 1 | x-ray diffraction | B | K | — |
| 6Q01 | TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 2 | x-ray diffraction | C, D | BEZ, K | 2 (best 0.49) |
| 6Q01 | TDP2 uba domain bound to ubiquitin at 0.85 ångströms resolution, crystal form 2 | x-ray diffraction | C, D | BEZ, K | — |
| O95551 | AlphaFold monomer V2.0 prediction for tyrosyl-DNA phosphodiesterase 2 (O95551) | predicted | A | — | 2 (best 0.56) |
Ligands
Experiment against prediction
- 5J3S chain A against the predicted model O95551: TM-score 0.99, RMSD 0.63 Å
- 5J3S chain A against the predicted model O95551: TM-score 0.99, RMSD 0.63 Å
- 5J3P chain B against the predicted model O95551: TM-score 0.99, RMSD 0.68 Å
- 5J3P chain B against the predicted model O95551: TM-score 0.99, RMSD 0.68 Å
- 5INO chain B against the predicted model O95551: TM-score 0.99, RMSD 0.70 Å
- 5INO chain B against the predicted model O95551: TM-score 0.99, RMSD 0.70 Å
- 5J3P chain A against the predicted model O95551: TM-score 0.99, RMSD 0.77 Å
- 5J3P chain A against the predicted model O95551: TM-score 0.99, RMSD 0.77 Å
- 5INO chain A against the predicted model O95551: TM-score 0.98, RMSD 0.91 Å
- 5INO chain A against the predicted model O95551: TM-score 0.98, RMSD 0.91 Å
Elsewhere
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