UniProt O95376
E3 ubiquitin-protein ligase ARIH2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (UniProt O95376), EC 2.3.2.31: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O95376
- Protein
- E3 ubiquitin-protein ligase ARIH2
- EC
- 2.3.2.31
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 17 · 2 records with a druggable one
Structures
5 records of O95376 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7OD1 | Crystal structure of RBR ubiquitin ligase ARIH2 | x-ray diffraction | A, B | ZN | 8 (best 0.68) |
| 7OD1 | Crystal structure of rbr ubiquitin ligase ARIH2 | x-ray diffraction | A, B | ZN | — |
| 7ONI | Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* | electron microscopy | H | ZN | 9 (best 0.76) |
| 7ONI | Structure of neddylated CUL5 C-terminal region-RBX2-ARIH2* | electron microscopy | H | ZN | — |
| O95376 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ARIH2 (O95376) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 4 records
Experiment against prediction
- 7OD1 chain B against the predicted model O95376: TM-score 0.97, RMSD 1.30 Å
- 7OD1 chain B against the predicted model O95376: TM-score 0.97, RMSD 1.30 Å
- 7OD1 chain A against the predicted model O95376: TM-score 0.96, RMSD 1.55 Å
- 7OD1 chain A against the predicted model O95376: TM-score 0.96, RMSD 1.55 Å
- 7ONI chain H against the predicted model O95376: TM-score 0.91, RMSD 2.10 Å
- 7ONI chain H against the predicted model O95376: TM-score 0.91, RMSD 2.10 Å
Elsewhere
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