UniProt O95298

NADH dehydrogenase [ubiquinone] 1 subunit C2 (O95298)

NADH dehydrogenase [ubiquinone] 1 subunit C2 (UniProt O95298): 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…

UniProt: O95298
Protein: NADH dehydrogenase [ubiquinone] 1 subunit C2
Experimental structures: 6
Predicted models: 1
Ligands: 2
Pockets: 13 · 6 records with a druggable one

Structures

7 records of O95298 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5XTC	Cryo-EM structure of human respiratory complex I transmembrane arm	electron microscopy	g	PLX, CDL	3 (best 0.83)
5XTC	Cryo-EM structure of human respiratory complex I transmembrane arm	electron microscopy	g	PLX, CDL	3 (best 0.83)
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	g	PLX, CDL	2 (best 0.89)
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	g	PLX, CDL	2 (best 0.89)
5XTH	Cryo-EM structure of human respiratory supercomplex I1III2IV1	electron microscopy	g	PLX, CDL	2 (best 0.87)
5XTI	Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2	electron microscopy	g, Bg	PLX, CDL	1 (best 0.89)
O95298	AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 subunit C2 (O95298)	predicted	A	—	—

Ligands

CDL · Cardiolipin · in 6 records
PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 6 records

Experiment against prediction

5XTI chain Bg against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å
5XTD chain g against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å
5XTD chain g against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å
5XTH chain g against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å
5XTC chain g against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å
5XTC chain g against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å
5XTI chain g against the predicted model O95298: TM-score 0.90, RMSD 1.42 Å

Elsewhere

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