UniProt O95243
Methyl-CpG-binding domain protein 4 (O95243)
Methyl-CpG-binding domain protein 4 (UniProt O95243), EC 3.2.2.-: 37 experimental structures on GenesisL1, 5 ligands bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O95243
- Protein
- Methyl-CpG-binding domain protein 4
- EC
- 3.2.2.-
- Experimental structures
- 37
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 5 · 0 records with a druggable one
Structures
37 records of O95243 in the MolNFT archive: 37 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MOE | Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA | solution nmr | A | — | — |
| 2MOE | Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA | solution nmr | A | — | — |
| 3IHO | The C-terminal glycosylase domain of human MBD4 | x-ray diffraction | A | — | — |
| 3IHO | The C-terminal glycosylase domain of human MBD4 | x-ray diffraction | A | — | — |
| 4DK9 | Crystal Structure of MBD4 Catalytic Domain Bound to Abasic DNA | x-ray diffraction | A | — | — |
| 4DK9 | Crystal structure of MBD4 catalytic domain bound to abasic DNA | x-ray diffraction | A | — | — |
| 4E9E | Structure of the glycosylase domain of MBD4 | x-ray diffraction | A | — | — |
| 4E9E | Structure of the glycosylase domain of MBD4 | x-ray diffraction | A | — | — |
| 4E9F | Structure of the glycosylase domain of MBD4 bound to AP site containing DNA | x-ray diffraction | A | — | — |
| 4E9F | Structure of the glycosylase domain of MBD4 bound to ap site containing DNA | x-ray diffraction | A | — | — |
| 4E9G | structure of the glycosylase domain of MBD4 bound to thymine containing DNA | x-ray diffraction | A | — | — |
| 4E9G | Structure of the glycosylase domain of MBD4 bound to thymine containing DNA | x-ray diffraction | A | — | — |
| 4E9H | structure of glycosylase domain of MBD4 bound to 5hmU containing DNA | x-ray diffraction | A | — | — |
| 4E9H | Structure of glycosylase domain of MBD4 bound to 5HMU containing DNA | x-ray diffraction | A | — | — |
| 4EA4 | Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA | x-ray diffraction | A | — | — |
| 4EA4 | Structure of the glycosylase domain of MBD4 bound to 5HMU-containing DNA | x-ray diffraction | A | — | — |
| 4EA5 | Structure of the glycoslyase domain of MBD4 bound to a 5hmU containing DNA | x-ray diffraction | A | — | — |
| 4EA5 | Structure of the glycoslyase domain of MBD4 bound to a 5HMU containing DNA | x-ray diffraction | A | — | — |
| 4LG7 | Crystal structure MBD4 MBD domain in complex with methylated CpG DNA | x-ray diffraction | A | — | — |
| 4LG7 | Crystal structure MBD4 mbd domain in complex with methylated cpg DNA | x-ray diffraction | A | — | — |
| 4OFA | Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding… | x-ray diffraction | A | — | — |
| 4OFA | Structural basis for thymine glycosylase activity on T:O6-methylg mismatch by methyl-cpg binding… | x-ray diffraction | A | — | — |
| 4OFE | Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding… | x-ray diffraction | A | — | — |
| 4OFE | Structural basis for thymine glycosylase activity on T:O6-methylg mismatch by methyl-cpg binding… | x-ray diffraction | A | — | — |
| 4OFH | Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding… | x-ray diffraction | A | — | — |
| 4OFH | Structural basis for thymine glycosylase activity on T:O6-methylg mismatch by methyl-cpg binding… | x-ray diffraction | A | — | — |
| 5CHZ | Structure of wild-type human MBD4 bound to a G:T mismatch | x-ray diffraction | A | MG | — |
| 5CHZ | Structure of wild-type human MBD4 bound to a G:T mismatch | x-ray diffraction | A | — | — |
| 6VJW | Crystal structure of WT hMBD4 complexed with T:G mismatch DNA | x-ray diffraction | A | — | 1 (best 0.26) |
| 6VJW | Crystal structure of wt HMBD4 complexed with T:G mismatch DNA | x-ray diffraction | A | ORP | — |
| 7KZ0 | Human MBD4 glycosylase domain bound to DNA containing substrate analog 2'-deoxy-pseudouridine | x-ray diffraction | A | K | 1 (best 0.40) |
| 7KZ0 | Human MBD4 glycosylase domain bound to DNA containing substrate analog 2'-deoxy-pseudouridine | x-ray diffraction | A | K | — |
| 7KZ1 | Human MBD4 glycosylase domain bound to DNA containing an abasic site | x-ray diffraction | A | NA | 1 (best 0.38) |
| 7KZ1 | Human MBD4 glycosylase domain bound to DNA containing an abasic site | x-ray diffraction | A | ORP, NA | — |
| 7KZG | Human MBD4 glycosylase domain bound to DNA containing oxacarbenium-ion analog 1-aza-2'-deoxyribose | x-ray diffraction | A | NA, CL | 2 (best 0.41) |
| 7KZG | Human MBD4 glycosylase domain bound to DNA containing oxacarbenium-ion analog 1-aza-2'-deoxyribose | x-ray diffraction | A | NA, CL | — |
| O95243 | AlphaFold monomer V2.0 prediction for methyl-cpg-binding domain protein 4 (O95243) | — | — | — |
Ligands
Elsewhere
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