UniProt O95168

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (O95168)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (UniProt O95168): 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against…

UniProt: O95168
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Experimental structures: 6
Predicted models: 1
Ligands: 2
Pockets: 10 · 4 records with a druggable one

Structures

7 records of O95168 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5XTC	Cryo-EM structure of human respiratory complex I transmembrane arm	electron microscopy	o	PLX, CDL	4 (best 0.86)
5XTC	Cryo-EM structure of human respiratory complex I transmembrane arm	electron microscopy	o	PLX	—
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	o	PLX, CDL	2 (best 0.89)
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	o	PLX	—
5XTH	Cryo-EM structure of human respiratory supercomplex I1III2IV1	electron microscopy	o	PLX, CDL	2 (best 0.87)
5XTI	Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2	electron microscopy	o, Bo	CDL, PLX	2 (best 0.89)
O95168	AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4…	predicted	A	—	—

Ligands

PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 6 records
CDL · Cardiolipin · in 4 records

Experiment against prediction

5XTH chain o against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å
5XTI chain o against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å
5XTI chain Bo against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å
5XTC chain o against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å
5XTC chain o against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å
5XTD chain o against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å
5XTD chain o against the predicted model O95168: TM-score 0.91, RMSD 1.40 Å

Elsewhere

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