UniProt O94907
Dickkopf-related protein 1 (O94907)
Dickkopf-related protein 1 (UniProt O94907): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O94907
- Protein
- Dickkopf-related protein 1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 2 records with a druggable one
Structures
11 records of O94907 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3S2K | Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. | x-ray diffraction | C | — | — |
| 3S2K | Structural basis of wnt signaling inhibition by dickkopf binding to LRP5/6. | x-ray diffraction | C | — | — |
| 3S8V | Crystal structure of LRP6-Dkk1 complex | x-ray diffraction | X | — | — |
| 3S8V | Crystal structure of LRP6-DKK1 complex | x-ray diffraction | X | — | — |
| 3SOQ | The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide | x-ray diffraction | Z | — | — |
| 3SOQ | The structure of the first ywtd beta propeller domain of LRP6 in complex with a DKK1 peptide | x-ray diffraction | Z | — | — |
| 5FWW | Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4) | x-ray diffraction | C | — | 3 (best 0.72) |
| 5FWW | Wnt modulator kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4) | x-ray diffraction | C | — | — |
| 5GJE | Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1 | electron microscopy | C | NAG | 3 (best 0.76) |
| 5GJE | Three-dimensional reconstruction of human LRP6 ectodomain complexed with DKK1 | electron microscopy | C | — | — |
| O94907 | AlphaFold monomer V2.0 prediction for dickkopf-related protein 1 (O94907) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 5GJE chain C against the predicted model O94907: TM-score 0.96, RMSD 0.68 Å
- 5GJE chain C against the predicted model O94907: TM-score 0.96, RMSD 0.68 Å
- 3S2K chain C against the predicted model O94907: TM-score 0.96, RMSD 0.68 Å
- 3S2K chain C against the predicted model O94907: TM-score 0.96, RMSD 0.68 Å
- 3S8V chain X against the predicted model O94907: TM-score 0.95, RMSD 0.90 Å
- 3S8V chain X against the predicted model O94907: TM-score 0.95, RMSD 0.90 Å
- 5FWW chain C against the predicted model O94907: TM-score 0.94, RMSD 0.92 Å
- 5FWW chain C against the predicted model O94907: TM-score 0.94, RMSD 0.92 Å
- 3SOQ chain Z against the predicted model O94907: TM-score 0.52, RMSD 0.81 Å
- 3SOQ chain Z against the predicted model O94907: TM-score 0.52, RMSD 0.81 Å
Elsewhere
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