UniProt O94874
E3 UFM1-protein ligase 1 (O94874)
E3 UFM1-protein ligase 1 (UniProt O94874), EC 2.3.2.-: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O94874
- Protein
- E3 UFM1-protein ligase 1
- EC
- 2.3.2.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 19 · 4 records with a druggable one
Structures
9 records of O94874 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8B9X | Chimeric protein of human UFM1 E3 ligase, UFL1, and DDRGK1 | x-ray diffraction | A, B | CL | 2 (best 0.37) |
| 8C0D | UFL1/DDRGK1 bound to UFC1 | x-ray diffraction | A, D | — | 5 (best 0.62) |
| 8OHD | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native) | electron microscopy | A | — | — |
| 8OJ0 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native) | electron microscopy | A | — | — |
| 8OJ5 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution) | electron microscopy | A | — | 1 (best 0.84) |
| 8OJ8 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | electron microscopy | A | — | — |
| 8QFC | UFL1 E3 ligase bound 60S ribosome | electron microscopy | B | — | 7 (best 0.77) |
| 8QFD | UFL1 E3 ligase bound 60S ribosome | electron microscopy | s | — | — |
| O94874 | AlphaFold monomer V2.0 prediction for E3 UFM1-protein ligase 1 (O94874) | predicted | A | — | 4 (best 0.64) |
Ligands
- CL · Chloride ion · in 1 record
Experiment against prediction
- 8C0D chain D against the predicted model O94874: TM-score 0.80, RMSD 1.39 Å
- 8C0D chain A against the predicted model O94874: TM-score 0.80, RMSD 1.37 Å
- 8B9X chain A against the predicted model O94874: TM-score 0.60, RMSD 2.07 Å
- 8B9X chain B against the predicted model O94874: TM-score 0.60, RMSD 2.06 Å
- 8QFC chain B against the predicted model O94874: TM-score 0.54, RMSD 5.38 Å
- 8OJ8 chain A against the predicted model O94874: TM-score 0.54, RMSD 3.49 Å
- 8OJ0 chain A against the predicted model O94874: TM-score 0.50, RMSD 5.39 Å
- 8OHD chain A against the predicted model O94874: TM-score 0.50, RMSD 5.35 Å
- 8OJ5 chain A against the predicted model O94874: TM-score 0.50, RMSD 5.33 Å
- 8B9X chain B against the predicted model Q96HY6: TM-score 0.35, RMSD 2.46 Å
Elsewhere
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