UniProt O94782
Ubiquitin carboxyl-terminal hydrolase 1 (O94782)
Ubiquitin carboxyl-terminal hydrolase 1 (UniProt O94782), EC 3.4.19.12: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O94782
- Protein
- Ubiquitin carboxyl-terminal hydrolase 1
- EC
- 3.4.19.12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 43 · 8 records with a druggable one
Structures
9 records of O94782 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7AY1 | Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI | electron microscopy | D | ZN | 5 (best 0.81) |
| 7AY1 | Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and fanci | electron microscopy | D | ZN | — |
| 7ZH3 | USP1 bound to ubiquitin conjugated to FANCD2 (focused refinement) | electron microscopy | D | ZN | 4 (best 0.55) |
| 7ZH4 | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) | electron microscopy | D | ZN, JDA | 3 (best 0.61) |
| 8A9J | Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 without ML323… | electron microscopy | D | ZN | 5 (best 0.81) |
| 8A9K | Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus… | electron microscopy | D | ZN, JDA | 6 (best 0.81) |
| 9FCI | USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement) | electron microscopy | D | ZN, A1IB8 | 5 (best 0.69) |
| 9FCJ | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement) | electron microscopy | D | ZN, JDA | 4 (best 0.79) |
| O94782 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 1 (O94782) | predicted | A | — | 11 (best 0.69) |
Ligands
- ZN · Zinc ion · in 8 records
- JDA · 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine · in 3 records
- A1IB8 · 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine · in 1 record
Experiment against prediction
- 8A9J chain D against the predicted model O94782: TM-score 0.97, RMSD 1.38 Å
- 7ZH3 chain D against the predicted model O94782: TM-score 0.97, RMSD 1.40 Å
- 7AY1 chain D against the predicted model O94782: TM-score 0.96, RMSD 1.54 Å
- 7AY1 chain D against the predicted model O94782: TM-score 0.96, RMSD 1.54 Å
- 9FCI chain D against the predicted model O94782: TM-score 0.95, RMSD 1.60 Å
- 7ZH4 chain D against the predicted model O94782: TM-score 0.94, RMSD 1.84 Å
- 8A9K chain D against the predicted model O94782: TM-score 0.94, RMSD 1.84 Å
- 9FCJ chain D against the predicted model O94782: TM-score 0.91, RMSD 2.10 Å
Elsewhere
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