UniProt O94760
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (O94760)
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (UniProt O94760), EC 3.5.3.18: 25 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 60 pockets. Binding sites, druggability and experiment against…
- UniProt
- O94760
- Protein
- N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
- EC
- 3.5.3.18
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 60 · 8 records with a druggable one
Structures
26 records of O94760 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JAI | DDAH1 complexed with citrulline | x-ray diffraction | A, B | CIR | 4 (best 0.81) |
| 2JAI | DDAH1 complexed with citrulline | x-ray diffraction | A, B | — | — |
| 2JAJ | DDAH1 complexed with L-257 | x-ray diffraction | A, B | D20 | 5 (best 0.82) |
| 2JAJ | DDAH1 complexed with L-257 | x-ray diffraction | A, B | — | — |
| 3I2E | Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (DDAH-1) | x-ray diffraction | A, B | — | — |
| 3I2E | Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (ddah-1) | x-ray diffraction | A, B | — | — |
| 3I4A | Crystal structure of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) in complex with… | x-ray diffraction | A, B | — | — |
| 3I4A | Crystal structure of dimethylarginine dimethylaminohydrolase-1 (ddah- 1) in complex with… | x-ray diffraction | A, B | — | — |
| 3P8E | Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with… | x-ray diffraction | A, B | — | — |
| 3P8E | Crystal structure of human dimethylarginine dimethylaminohydrolase-1 (ddah-1) covalently bound with… | x-ray diffraction | A, B | — | — |
| 3P8P | Crystal Structure of Human Dimethylarginine Dimethylaminohydrolase-1 (DDAH-1) variant C274S bound… | x-ray diffraction | A, B | — | — |
| 3P8P | Crystal structure of human dimethylarginine dimethylaminohydrolase-1 (ddah-1) variant C274S bound… | x-ray diffraction | A, B | — | — |
| 6DGE | Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with… | x-ray diffraction | A | GBG | 2 (best 0.81) |
| 6DGE | Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with… | x-ray diffraction | A | GBG | — |
| 6SZP | High resolution crystal structure of human DDAH-1 in complex with… | x-ray diffraction | A | M3B | 2 (best 0.82) |
| 6SZP | High resolution crystal structure of human ddah-1 in complex with N… | x-ray diffraction | A | M3B | — |
| 6SZQ | Crystal structure of human DDAH-1 | x-ray diffraction | A, B, C, D, E, F | — | 18 (best 0.86) |
| 6SZQ | Crystal structure of human ddah-1 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 7ULU | Human DDAH1 soaked with its inhibitor ClPyrAA | x-ray diffraction | A, B | NOU | 4 (best 0.83) |
| 7ULV | Human DDAH1 soaked with its inactivator S-((4-chloropyridin-2-yl)methyl)-L-cysteine | x-ray diffraction | A, B, C, D, E, F | NO6 | 20 (best 0.81) |
| 7ULX | Human DDAH1 soaked with its inhibitor N4-(4-chloropyridin-2-yl)-L-asparagine | x-ray diffraction | A, B | NQ6 | 5 (best 0.82) |
| 7USZ | Human DDAH-1, holo (Zn-bound) form | x-ray diffraction | A, B | ZN, CL | — |
| 7USZ | Human ddah-1, holo (zn-bound) form | x-ray diffraction | A, B | ZN, CL | — |
| 7UT0 | Human DDAH-1, apo form | x-ray diffraction | A, B | — | — |
| 7UT0 | Human ddah-1, apo form | x-ray diffraction | A, B | — | — |
| O94760 | AlphaFold monomer V2.0 prediction for N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (O94760) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
- GBG · N~6~-[(1E)-2-chloroethanimidoyl]-L-lysine · in 2 records
- M3B · (1~{S})-~{N}'-(4-azanylbutyl)-~{N}"-(2-methoxyethyl) methanetriamine · in 2 records
- ZN · Zinc ion · in 2 records
- CIR · Citrulline · in 1 record
- D20 · N~5~-{imino[(2-methoxyethyl)amino]methyl}-L-ornithine · in 1 record
- NO6 · S-[(pyridin-2-yl)methyl]-L-cysteine · in 1 record
- NOU · (2S)-2-amino-4-[(pyridin-2-yl)amino]butanoic acid · in 1 record
- NQ6 · N-(pyridin-2-yl)-L-asparagine · in 1 record
Experiment against prediction
- 2JAI chain A against the predicted model O94760: TM-score 1.00, RMSD 0.28 Å
- 2JAI chain A against the predicted model O94760: TM-score 1.00, RMSD 0.28 Å
- 7USZ chain A against the predicted model O94760: TM-score 0.99, RMSD 0.50 Å
- 7USZ chain A against the predicted model O94760: TM-score 0.99, RMSD 0.50 Å
- 2JAJ chain A against the predicted model O94760: TM-score 0.99, RMSD 0.51 Å
- 2JAJ chain A against the predicted model O94760: TM-score 0.99, RMSD 0.51 Å
- 7ULU chain A against the predicted model O94760: TM-score 0.99, RMSD 0.65 Å
- 6SZQ chain A against the predicted model O94760: TM-score 0.99, RMSD 0.63 Å
- 6SZQ chain A against the predicted model O94760: TM-score 0.99, RMSD 0.63 Å
- 7ULX chain A against the predicted model O94760: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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