UniProt O88844
Isocitrate dehydrogenase [NADP] cytoplasmic (O88844)
Isocitrate dehydrogenase [NADP] cytoplasmic (UniProt O88844), EC 1.1.1.42: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O88844
- Protein
- Isocitrate dehydrogenase [NADP] cytoplasmic
- EC
- 1.1.1.42
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 53 · 4 records with a druggable one
Structures
7 records of O88844 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5YZH | Crystal Structure of Mouse Cytosolic Isocitrate Dehydrogenase | x-ray diffraction | A, B | NAP | 8 (best 0.80) |
| 5YZH | Crystal structure of mouse cytosolic isocitrate dehydrogenase | x-ray diffraction | A, B | NAP | — |
| 5YZI | Crystal Structure of Mouse Cytosolic Isocitrate Dehydrogenase complexed with Cadmium | x-ray diffraction | A, B | CD, NAP | 9 (best 0.79) |
| 5YZI | Crystal structure of mouse cytosolic isocitrate dehydrogenase complexed with cadmium | x-ray diffraction | A, B | CD, NAP | — |
| 8KIB | NADP+-dependent cytosolic isocitrate dehydrogenase complexed with oxaloacetate | x-ray diffraction | A, B, C, D | NAP, OAA | 17 (best 0.83) |
| 8W49 | mouse isocitrate dehydrogenase with isocitrate and magnesium | x-ray diffraction | A, B, C, D | NAP, MG, ICT | 19 (best 0.85) |
| O88844 | AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NADP] cytoplasmic (O88844) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5YZI chain A against the predicted model O88844: TM-score 0.98, RMSD 0.94 Å
- 5YZI chain A against the predicted model O88844: TM-score 0.98, RMSD 0.94 Å
- 8W49 chain C against the predicted model O88844: TM-score 0.98, RMSD 0.96 Å
- 5YZI chain B against the predicted model O88844: TM-score 0.98, RMSD 0.97 Å
- 5YZI chain B against the predicted model O88844: TM-score 0.98, RMSD 0.97 Å
- 5YZH chain B against the predicted model O88844: TM-score 0.98, RMSD 0.98 Å
- 5YZH chain B against the predicted model O88844: TM-score 0.98, RMSD 0.98 Å
- 8KIB chain C against the predicted model O88844: TM-score 0.98, RMSD 0.99 Å
- 8KIB chain A against the predicted model O88844: TM-score 0.98, RMSD 1.07 Å
- 8W49 chain B against the predicted model O88844: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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