UniProt O75909
Cyclin-K (O75909)
Cyclin-K (UniProt O75909): 26 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 75 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75909
- Protein
- Cyclin-K
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 75 · 12 records with a druggable one
Structures
27 records of O75909 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I53 | Crystal structure of Cyclin K | x-ray diffraction | A | — | — |
| 2I53 | Crystal structure of cyclin K | x-ray diffraction | A | — | — |
| 4CXA | Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP | x-ray diffraction | B, D | — | — |
| 4CXA | Crystal structure of the human CDK12-cyclin K complex bound to amppnp | x-ray diffraction | B, D | — | — |
| 4NST | Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride | x-ray diffraction | B, D | — | — |
| 4NST | Crystal structure of human CDK12/CYCLIN K in complex with ADP-aluminum fluoride | x-ray diffraction | B, D | — | — |
| 4UN0 | Crystal structure of the human CDK12-cyclinK complex | x-ray diffraction | A, B | — | — |
| 4UN0 | Crystal structure of the human CDK12-cyclink complex | x-ray diffraction | A, B | — | — |
| 5EFQ | Crystal structure of human CDK13/CYCLIN K in complex with ADP-aluminum fluoride | x-ray diffraction | B, D | — | — |
| 6B3E | Crystal structure of human CDK12/CyclinK in complex with an inhibitor | x-ray diffraction | B, D | — | 9 (best 0.74) |
| 6B3E | Crystal structure of human CDK12/CYCLINK in complex with an inhibitor | x-ray diffraction | B, D | — | — |
| 6CKX | Structure of CDK12/CycK in complex with a small molecule inhibitor… | x-ray diffraction | B, D | MG | 11 (best 0.51) |
| 6CKX | Structure of CDK12/CYCK in complex with a small molecule inhibitor N… | x-ray diffraction | B, D | MG | — |
| 6TD3 | Structure of DDB1 bound to CR8-engaged CDK12-cyclink | x-ray diffraction | C, F, I | — | — |
| 7NXJ | Crystal structure of human CDK13/CYCLIN K in complex with the inhibitor THZ531 | x-ray diffraction | B, D | — | — |
| 7NXK | Crystal structure of human CDK12/CYCLIN K in complex with the inhibitor bsj-01-175 | x-ray diffraction | B, D | — | — |
| 8BU3 | Structure of DDB1 bound to DS19-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | SO4 | 5 (best 0.67) |
| 8BU5 | Structure of DDB1 bound to SR-4835-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | — | 5 (best 0.66) |
| 8BU6 | Structure of DDB1 bound to DS55-engaged CDK12-cyclin K | x-ray diffraction | I, F, C | SO4 | 5 (best 0.70) |
| 8BU7 | Structure of DDB1 bound to 21195-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | SO4 | 8 (best 0.82) |
| 8BUB | Structure of DDB1 bound to dCeMM4-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | — | 6 (best 0.69) |
| 8BUC | Structure of DDB1 bound to dCeMM3-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | SO4 | 5 (best 0.67) |
| 8BUD | Structure of DDB1 bound to Z7-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | SO4 | 5 (best 0.66) |
| 8BUG | Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | — | 6 (best 0.69) |
| 8BUH | Structure of DDB1 bound to WX3-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | SO4 | 5 (best 0.66) |
| 8BUJ | Structure of DDB1 bound to DS06-engaged CDK12-cyclin K | x-ray diffraction | C, F, I | SO4 | 5 (best 0.69) |
| O75909 | AlphaFold monomer V2.0 prediction for cyclin-K (O75909) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4UN0 chain B against the predicted model O75909: TM-score 0.99, RMSD 0.60 Å
- 4UN0 chain B against the predicted model O75909: TM-score 0.99, RMSD 0.60 Å
- 6B3E chain D against the predicted model O75909: TM-score 0.99, RMSD 0.70 Å
- 6B3E chain D against the predicted model O75909: TM-score 0.99, RMSD 0.70 Å
- 5EFQ chain D against the predicted model O75909: TM-score 0.99, RMSD 0.80 Å
- 7NXK chain D against the predicted model O75909: TM-score 0.99, RMSD 0.76 Å
- 4NST chain D against the predicted model O75909: TM-score 0.99, RMSD 0.81 Å
- 4NST chain D against the predicted model O75909: TM-score 0.99, RMSD 0.81 Å
- 6B3E chain B against the predicted model O75909: TM-score 0.99, RMSD 0.86 Å
- 6B3E chain B against the predicted model O75909: TM-score 0.99, RMSD 0.86 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.