UniProt O75586
Mediator of RNA polymerase II transcription subunit 6 (O75586)
Mediator of RNA polymerase II transcription subunit 6 (UniProt O75586): 9 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75586
- Protein
- Mediator of RNA polymerase II transcription subunit 6
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 5 · 3 records with a druggable one
Structures
10 records of O75586 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | F | — | 1 (best 0.74) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | F | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | f | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | f | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | F | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | a | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | a | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | f | — | 2 (best 0.81) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | F | — | 2 (best 0.83) |
| O75586 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 6 (O75586) | predicted | A | — | — |
Experiment against prediction
- 7NVR chain a against the predicted model O75586: TM-score 0.75, RMSD 2.81 Å
- 7NVR chain a against the predicted model O75586: TM-score 0.75, RMSD 2.81 Å
- 8GXQ chain f against the predicted model O75586: TM-score 0.67, RMSD 2.59 Å
- 7ENA chain f against the predicted model O75586: TM-score 0.67, RMSD 2.68 Å
- 7ENJ chain F against the predicted model O75586: TM-score 0.67, RMSD 2.70 Å
- 7EMF chain F against the predicted model O75586: TM-score 0.67, RMSD 2.70 Å
- 7EMF chain F against the predicted model O75586: TM-score 0.67, RMSD 2.70 Å
- 7ENC chain f against the predicted model O75586: TM-score 0.67, RMSD 2.82 Å
- 8TQW chain F against the predicted model O75586: TM-score 0.61, RMSD 3.42 Å
Elsewhere
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