UniProt O75448
Mediator of RNA polymerase II transcription subunit 24 (O75448)
Mediator of RNA polymerase II transcription subunit 24 (UniProt O75448): 11 experimental structures and 1 predicted model on GenesisL1, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75448
- Protein
- Mediator of RNA polymerase II transcription subunit 24
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 21 · 7 records with a druggable one
Structures
12 records of O75448 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | X | — | 3 (best 0.86) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | X | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | x | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | x | — | — |
| 7ENJ | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | electron microscopy | X | — | 3 (best 0.86) |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | X | — | — |
| 7LBM | Structure of the human Mediator-bound transcription pre-initiation complex | electron microscopy | 2 | — | 4 (best 0.84) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | x | — | 2 (best 0.87) |
| 8GXS | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | electron microscopy | x | — | 2 (best 0.86) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | X | — | 3 (best 0.86) |
| 8TRH | The IDRc bound human core Mediator complex | electron microscopy | X | — | 4 (best 0.85) |
| O75448 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 24… | predicted | A | — | — |
Experiment against prediction
- 8GXQ chain x against the predicted model O75448: TM-score 0.97, RMSD 1.88 Å
- 8GXS chain x against the predicted model O75448: TM-score 0.97, RMSD 1.88 Å
- 7EMF chain X against the predicted model O75448: TM-score 0.97, RMSD 1.88 Å
- 7EMF chain X against the predicted model O75448: TM-score 0.97, RMSD 1.88 Å
- 7LBM chain 2 against the predicted model O75448: TM-score 0.96, RMSD 2.03 Å
- 8TRH chain X against the predicted model O75448: TM-score 0.95, RMSD 2.55 Å
- 8TQW chain X against the predicted model O75448: TM-score 0.93, RMSD 2.97 Å
- 7ENJ chain X against the predicted model O75448: TM-score 0.79, RMSD 5.42 Å
- 7ENJ chain X against the predicted model O75448: TM-score 0.79, RMSD 5.42 Å
- 7ENA chain x against the predicted model O75448: TM-score 0.78, RMSD 4.77 Å
Elsewhere
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