UniProt O66842
NADH-quinone oxidoreductase subunit E (O66842)
NADH-quinone oxidoreductase subunit E (UniProt O66842), EC 1.6.5.11, 7.1.1.-: 45 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 174 pockets. Binding sites, druggability and experiment against…
- UniProt
- O66842
- Protein
- NADH-quinone oxidoreductase subunit E
- EC
- 1.6.5.11, 7.1.1.-
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 174 · 24 records with a druggable one
Structures
46 records of O66842 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HL2 | wild-type NuoEF from Aquifex aeolicus - oxidized form | x-ray diffraction | A, C | FES, SO4, CL | — |
| 6HL2 | Wild-type nuoef from aquifex aeolicus - oxidized form | x-ray diffraction | A, C | FES, SO4, CL | — |
| 6HL3 | wild-type NuoEF from Aquifex aeolicus - oxidized form bound to NAD+ | x-ray diffraction | A, C | FES, CL, SO4 | — |
| 6HL3 | Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+ | x-ray diffraction | A, C | FES, CL, SO4 | — |
| 6HL4 | wild-type NuoEF from Aquifex aeolicus - reduced form | x-ray diffraction | A, C | FES | — |
| 6HL4 | Wild-type nuoef from aquifex aeolicus - reduced form | x-ray diffraction | A, C | FES | — |
| 6HLA | wild-type NuoEF from Aquifex aeolicus - reduced form bound to NADH | x-ray diffraction | A, C | FES | — |
| 6HLA | Wild-type nuoef from aquifex aeolicus - reduced form bound to NADH | x-ray diffraction | A, C | FES | — |
| 6HLI | wild-type NuoEF from Aquifex aeolicus - reduced form bound to NAD+ | x-ray diffraction | A, C | FES | — |
| 6HLI | Wild-type nuoef from aquifex aeolicus - reduced form bound to NAD+ | x-ray diffraction | A, C | FES | — |
| 6HLJ | Variant G129S of NuoEF from Aquifex aeolicus - oxidized from | x-ray diffraction | A, C | FES | — |
| 6HLJ | Variant G129S of nuoef from aquifex aeolicus - oxidized from | x-ray diffraction | A, C | FES | — |
| 6HLM | Variant G129D of NuoEF from Aquifex aeolicus bound to NAD+ | x-ray diffraction | A, C | FES | — |
| 6HLM | Variant G129D of nuoef from aquifex aeolicus bound to NAD+ | x-ray diffraction | A, C | FES | — |
| 6Q9C | Crystal structure of Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE and NuoF bound to NADH… | x-ray diffraction | A, C | FES, SO4 | 8 (best 0.77) |
| 6Q9C | Crystal structure of aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe and nuof bound to… | x-ray diffraction | A, C | FES, SO4 | — |
| 6Q9G | Crystal structure of reduced Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE G129D and NuoF… | x-ray diffraction | A, C | FES, SO4 | — |
| 6Q9G | Crystal structure of reduced aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe G129D and… | x-ray diffraction | A, C | FES, SO4 | — |
| 6Q9J | Crystal structure of reduced Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE G129S and NuoF… | x-ray diffraction | A, C | FES, SO4 | 8 (best 0.76) |
| 6Q9J | Crystal structure of reduced aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe G129S and… | x-ray diffraction | A, C | FES, SO4 | — |
| 6Q9K | Crystal structure of reduced Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE and NuoF S96M… | x-ray diffraction | A, C | FES, SO4 | 8 (best 0.75) |
| 6Q9K | Crystal structure of reduced aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe and nuof… | x-ray diffraction | A, C | FES, SO4 | — |
| 6R7P | Crystal structure of oxidized Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE and NuoF S96M | x-ray diffraction | A, C | FES, CL | 8 (best 0.75) |
| 6R7P | Crystal structure of oxidized aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe and nuof… | x-ray diffraction | A, C | FES, CL | — |
| 6SAQ | wild-type NuoEF from Aquifex aeolicus bound to NADH-OH | x-ray diffraction | A, C | FES | 4 (best 0.60) |
| 6SAQ | Wild-type nuoef from aquifex aeolicus bound to NADH-oh | x-ray diffraction | A, C | FES | — |
| 7Q5Y | Structure of NADH:ubichinon oxidoreductase (complex I) of the hyperthermophilic eubacterium Aquifex… | x-ray diffraction | E, K, Q, W | FES | 6 (best 0.73) |
| 8QG1 | Crystal structure of oxidized respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | A, C | FES, SO4, CL | 7 (best 0.76) |
| 8QGW | Crystal structure of oxidized respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | A, C | FES, SO4, NA | 7 (best 0.77) |
| 8QH4 | Crystal structure of reduced respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | A, C | FES, SO4, NA | 7 (best 0.76) |
| 8QH7 | Crystal structure of respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to reduced… | x-ray diffraction | A, C | FES, SO4, NA | 7 (best 0.77) |
| 8QHK | Crystal structure of reduced respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | A, C | FES, SO4, NA | 6 (best 0.76) |
| 9FDJ | Crystal structure of the NuoEF variant R66G (NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | A, C | FES, SO4, CL, NA | 7 (best 0.75) |
| 9FDK | Crystal Structure of oxidized NuoEF variant R66G(NuoF) from Aquifex aeolicus | x-ray diffraction | A, C | FES, SO4, CL, NA | 8 (best 0.76) |
| 9FDV | Crystal Structure of reduced NuoEF variant R66G(NuoF) from Aquifex aeolicus | x-ray diffraction | A, C | FES, SO4, CL, NA | 7 (best 0.76) |
| 9FE0 | Crystal Structure of reduced NuoEF variant R66G(NuoF) from Aquifex aeolicus bound to NAD+ | x-ray diffraction | A, C | FES, SO4, CL, NA | 7 (best 0.76) |
| 9FE5 | Crystal Structure of NuoEF variant R66G(NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | A, C | FES, SO4, CL | 7 (best 0.75) |
| 9FE7 | Crystal Structure of oxidized NuoEF variant P228R(NuoF) from Aquifex aeolicus | x-ray diffraction | A, C | FES, SO4, NA, CL | 7 (best 0.75) |
| 9FE8 | Crystal Structure of reduced NuoEF variant P228R(NuoF) from Aquifex aeolicus | x-ray diffraction | A, C | FES, SO4, NA | 6 (best 0.76) |
| 9FEA | Crystal Structure of reduced NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NAD+ | x-ray diffraction | A, C | FES, SO4, CL, NA | 7 (best 0.76) |
| 9FIF | Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | A, C | FES, SO4, NA | 8 (best 0.76) |
| 9FIH | Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | A, C | FES, SO4, NA | 7 (best 0.76) |
| 9FII | Crystal Structure of oxidized NuoEF variant E222K(NuoF) from Aquifex aeolicus | x-ray diffraction | A, C | FES, NA, CL | 9 (best 0.71) |
| 9FIJ | Crystal Structure of reduced NuoEF variant E222K(NuoF) from Aquifex aeolicus | x-ray diffraction | A, C | FES, NA, SO4, CL | 9 (best 0.73) |
| 9FIL | Crystal Structure of reduced NuoEF variant E222K(NuoF) from Aquifex aeolicus bound to NAD+ | x-ray diffraction | A, C | FES, NA, CL | 9 (best 0.73) |
| O66842 | AlphaFold monomer V2.0 prediction for NADH-quinone oxidoreductase subunit E (O66842) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6R7P chain A against the predicted model O66842: TM-score 0.98, RMSD 0.69 Å
- 6R7P chain A against the predicted model O66842: TM-score 0.98, RMSD 0.69 Å
- 6HLM chain A against the predicted model O66842: TM-score 0.98, RMSD 0.70 Å
- 6HLM chain A against the predicted model O66842: TM-score 0.98, RMSD 0.70 Å
- 7Q5Y chain Q against the predicted model O66842: TM-score 0.98, RMSD 0.71 Å
- 6R7P chain C against the predicted model O66842: TM-score 0.98, RMSD 0.72 Å
- 6R7P chain C against the predicted model O66842: TM-score 0.98, RMSD 0.72 Å
- 6SAQ chain A against the predicted model O66842: TM-score 0.98, RMSD 0.72 Å
- 6SAQ chain A against the predicted model O66842: TM-score 0.98, RMSD 0.72 Å
- 6Q9G chain A against the predicted model O66842: TM-score 0.98, RMSD 0.72 Å
Elsewhere
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