UniProt O60931
Isoform 2 of Cystinosin (O60931)
Isoform 2 of Cystinosin (UniProt O60931): 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60931
- Protein
- Isoform 2 of Cystinosin
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 3 records with a druggable one
Structures
4 records of O60931 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8DKI | Cryo-EM structure of cystinosin in a lumen-open state | electron microscopy | P | — | 3 (best 0.78) |
| 8DKM | Cryo-EM structure of cystine-bound cystinosin in a lumen-open state | electron microscopy | P | IYY | 2 (best 0.78) |
| 8DKX | Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5 | electron microscopy | P | — | 2 (best 0.76) |
| O60931 | AlphaFold monomer V2.0 prediction for cystinosin (O60931) | predicted | A | — | — |
Ligands
- IYY · L-cystine · in 1 record
Experiment against prediction
- 8DKX chain P against the predicted model O60931: TM-score 0.97, RMSD 1.16 Å
- 8DKM chain P against the predicted model O60931: TM-score 0.85, RMSD 2.96 Å
- 8DKI chain P against the predicted model O60931: TM-score 0.84, RMSD 3.08 Å
Elsewhere
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