UniProt O60911
Cathepsin L2 (O60911)
Cathepsin L2 (UniProt O60911), EC 3.4.22.43: 28 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60911
- Protein
- Cathepsin L2
- EC
- 3.4.22.43
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 47 · 19 records with a druggable one
Structures
29 records of O60911 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FH0 | Crystal structure of human cathepsin V complexed with an irreversible vinyl sulfone inhibitor | x-ray diffraction | A, B | — | — |
| 1FH0 | Crystal structure of human cathepsin V complexed with an irreversible vinyl sulfone inhibitor | x-ray diffraction | A, B | — | — |
| 3H6S | Structure of clitocypin - cathepsin V complex | x-ray diffraction | A, B, C, D | — | — |
| 3H6S | Structure of clitocypin - cathepsin V complex | x-ray diffraction | A, B, C, D | — | — |
| 3KFQ | Unreduced cathepsin V in complex with stefin A | x-ray diffraction | A, B | — | — |
| 3KFQ | Unreduced cathepsin V in complex with stefin a | x-ray diffraction | A, B | — | — |
| 7PK4 | Tick salivary cystatin Ricistatin in complex with cathepsin V | x-ray diffraction | A | — | 2 (best 0.38) |
| 7Q8D | Peptide TRESEDLE in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.79) |
| 7Q8F | Peptide GNYKEAKK in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 3 (best 0.78) |
| 7Q8G | Peptide ALAASS in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.78) |
| 7Q8H | Peptide EVCKKKK in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 3 (best 0.78) |
| 7Q8I | Peptide AVAEKQ in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL, NA | 3 (best 0.78) |
| 7Q8J | Peptide IILKEK in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | — | 1 (best 0.79) |
| 7Q8K | Peptide LLKVAL in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.78) |
| 7Q8L | Peptide VPCGTAHE in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 1 (best 0.78) |
| 7Q8M | Peptide KPKKKTK in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | — | 3 (best 0.79) |
| 7Q8N | Peptide KKYDAFLA in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.78) |
| 7Q8O | Peptide LLSGKE in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL | 3 (best 0.78) |
| 7Q8P | Peptide LLKVAL in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL | 3 (best 0.77) |
| 7Q8Q | Peptide RLSAKP in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL | — |
| 7Q9H | Peptide LLKAVAEKQ in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 3 (best 0.79) |
| 7QFF | Peptide VACKSSQP in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.77) |
| 7QFH | Peptide AYFKKVL in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL, NH2 | 3 (best 0.78) |
| 7QGW | Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections | x-ray diffraction | A, B | CL, RN2 | — |
| 7QHJ | Peptide GAKSAA in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL, NA | 3 (best 0.78) |
| 7QHK | Peptide QLRQQE in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.78) |
| 7QNS | Peptide VYEKKP in complex with human cathepsin V C25S mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.78) |
| 7QO2 | Peptide GAKSAA in complex with human cathepsin V C25A mutant | x-ray diffraction | AA, BA | CL | 2 (best 0.78) |
| O60911 | AlphaFold monomer V2.0 prediction for cathepsin L2 (O60911) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7PK4 chain A against the predicted model O60911: TM-score 1.00, RMSD 0.32 Å
- 7Q8N chain BA against the predicted model O60911: TM-score 0.99, RMSD 0.72 Å
- 3H6S chain C against the predicted model O60911: TM-score 0.99, RMSD 0.74 Å
- 3H6S chain C against the predicted model O60911: TM-score 0.99, RMSD 0.74 Å
- 7Q8L chain BA against the predicted model O60911: TM-score 0.99, RMSD 0.75 Å
- 3KFQ chain A against the predicted model O60911: TM-score 0.99, RMSD 0.74 Å
- 3KFQ chain A against the predicted model O60911: TM-score 0.99, RMSD 0.74 Å
- 7Q8D chain BA against the predicted model O60911: TM-score 0.99, RMSD 0.74 Å
- 7Q8G chain BA against the predicted model O60911: TM-score 0.99, RMSD 0.73 Å
- 7QFF chain BA against the predicted model O60911: TM-score 0.99, RMSD 0.76 Å
Elsewhere
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