UniProt O60493
Sorting nexin-3 (O60493)
Sorting nexin-3 (UniProt O60493): 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60493
- Protein
- Sorting nexin-3
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 12 · 3 records with a druggable one
Structures
13 records of O60493 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MXC | Solution structure of the full length sorting nexin 3 | solution nmr | A | — | — |
| 2MXC | Solution structure of the full length sorting nexin 3 | solution nmr | A | — | — |
| 2YPS | Crystal structure of the PX domain of human sorting nexin 3 | x-ray diffraction | A, B, C, D | — | — |
| 2YPS | Crystal structure of the px domain of human sorting nexin 3 | x-ray diffraction | A, B, C, D | — | — |
| 5F0J | Structure of retromer VPS26-VPS35 subunits bound to SNX3 | x-ray diffraction | C | SO4 | — |
| 5F0J | Structure of retromer VPS26-VPS35 subunits bound to SNX3 | x-ray diffraction | C | — | — |
| 5F0L | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | x-ray diffraction | C | SO4 | 4 (best 0.67) |
| 5F0L | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | x-ray diffraction | C | — | — |
| 5F0M | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (SeMet labeled) | x-ray diffraction | C | SO4 | 3 (best 0.69) |
| 5F0M | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (semet labeled) | x-ray diffraction | C | — | — |
| 5F0P | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (SeMet labeled) | x-ray diffraction | C | SO4 | 4 (best 0.69) |
| 5F0P | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (semet labeled) | x-ray diffraction | C | — | — |
| O60493 | AlphaFold monomer V2.0 prediction for sorting nexin-3 (O60493) | predicted | A | — | 1 (best 0.40) |
Ligands
- SO4 · Sulfate ion · in 4 records
Experiment against prediction
- 2YPS chain C against the predicted model O60493: TM-score 0.94, RMSD 1.32 Å
- 2YPS chain C against the predicted model O60493: TM-score 0.94, RMSD 1.32 Å
- 2YPS chain B against the predicted model O60493: TM-score 0.94, RMSD 1.35 Å
- 2YPS chain B against the predicted model O60493: TM-score 0.94, RMSD 1.35 Å
- 2YPS chain D against the predicted model O60493: TM-score 0.92, RMSD 1.82 Å
- 2YPS chain D against the predicted model O60493: TM-score 0.92, RMSD 1.82 Å
- 2YPS chain A against the predicted model O60493: TM-score 0.89, RMSD 1.87 Å
- 2YPS chain A against the predicted model O60493: TM-score 0.89, RMSD 1.87 Å
- 5F0J chain C against the predicted model O60493: TM-score 0.89, RMSD 1.57 Å
- 5F0J chain C against the predicted model O60493: TM-score 0.89, RMSD 1.57 Å
Elsewhere
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